756525-99-2 Usage
Description
alpha-MaleiMidopropionyl-oMega-succiniMidyl-4(ethylene glycol), also known as Mal-amido-PEG4-NHS, is a PEG linker containing a maleimide group and an NHS ester. It is a cross-linking compound that enhances solubility in aqueous media due to its hydrophilic PEG spacer. The NHS ester allows for the labeling of primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group can react with a thiol group to form a covalent bond, enabling the connection of biomolecules with a thiol.
Uses
Used in Anticancer Applications:
alpha-MaleiMidopropionyl-oMega-succiniMidyl-4(ethylene glycol) is used as a cross-linking agent for the lysosomal acid-triggered release of anticancer drugs. This application aids in the targeted delivery and controlled release of therapeutic agents, enhancing the efficacy of cancer treatments.
Used in Drug Delivery Systems:
In the pharmaceutical industry, alpha-MaleiMidopropionyl-oMega-succiniMidyl-4(ethylene glycol) is used as a PEG linker for improving the solubility, stability, and bioavailability of drugs. The hydrophilic PEG spacer and reactive groups facilitate the attachment of drugs to biomolecules, creating more effective drug conjugates.
Used in Protein and Biomolecule Labeling:
In the biotechnology industry, alpha-MaleiMidopropionyl-oMega-succiniMidyl-4(ethylene glycol) is used as a labeling agent for proteins, amine-modified oligonucleotides, and other amine-containing molecules. The NHS ester allows for the covalent attachment of these molecules, enabling their detection, tracking, or manipulation in various applications.
Used in Research and Development:
In the field of scientific research, alpha-MaleiMidopropionyl-oMega-succiniMidyl-4(ethylene glycol) is used as a versatile reagent for the study of biomolecular interactions, protein engineering, and the development of novel bioconjugates. Its unique properties make it a valuable tool for advancing our understanding of biological systems and creating new therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 756525-99-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,5,6,5,2 and 5 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 756525-99:
(8*7)+(7*5)+(6*6)+(5*5)+(4*2)+(3*5)+(2*9)+(1*9)=202
202 % 10 = 2
So 756525-99-2 is a valid CAS Registry Number.
756525-99-2Relevant articles and documents
Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof
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, (2019/11/11)
Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo and in intro, and an intermediate, a pharmaceutical composition, and uses of the antibody drug conjugate. The antibody drug conjugate has simple synthetic steps and a high yield.
ANTI-CD22 ANTIBODY-DRUG CONJUGATES AND METHODS OF USING THEREOF
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Paragraph 0273; 0281, (2016/05/09)
The present disclosure provides anti-CD22 antibody-drug conjugates comprising a hydrophilic self-immolative linker. The present disclosures further provide compositions and methods for treating cancers.