Several β-amino tetrazole analogs of gabapentin 1 and pregabalin 2 were prepared by one of two convergent, highly efficient routes, and their affinity for the α2-δ protein examined. Two select compounds with potent affinity for α2-δ,
Schwarz, Jacob B.,Colbry, Norman L.,Zhu, Zhijian,Nichelson, Brian,Barta, Nancy S.,Lin, Kristin,Hudack, Raymond A.,Gibbons, Sian E.,Galatsis, Paul,DeOrazio, Russell J.,Manning, David D.,Vartanian, Mark G.,Kinsora, Jack J.,Lotarski, Susan M.,Li, Zheng,Dickerson, Melvin R.,El-Kattan, Ayman,Thorpe, Andrew J.,Donevan, Sean D.,Taylor, Charles P.,Wustrow, David J.
p. 3559 - 3563
(2007/10/03)
TETRAZOLE AND OXADIAZOLONE SUBSTITUTED β-AMINO ACID DERIVATIVES
This invention relates to novel tetrazole and oxadiazalone β-amino acids derivatives of the formula (I, II), wherein G is (III, IV) wherein R1 through R4 are defined as in the specification, pharmaceutical compositions containing the
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Page 39
(2010/02/08)
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