758696-64-9Relevant articles and documents
Carboxylate bioisosteres of pregabalin
Schwarz, Jacob B.,Colbry, Norman L.,Zhu, Zhijian,Nichelson, Brian,Barta, Nancy S.,Lin, Kristin,Hudack, Raymond A.,Gibbons, Sian E.,Galatsis, Paul,DeOrazio, Russell J.,Manning, David D.,Vartanian, Mark G.,Kinsora, Jack J.,Lotarski, Susan M.,Li, Zheng,Dickerson, Melvin R.,El-Kattan, Ayman,Thorpe, Andrew J.,Donevan, Sean D.,Taylor, Charles P.,Wustrow, David J.
, p. 3559 - 3563 (2007/10/03)
Several β-amino tetrazole analogs of gabapentin 1 and pregabalin 2 were prepared by one of two convergent, highly efficient routes, and their affinity for the α2-δ protein examined. Two select compounds with potent affinity for α2-δ,
