- Intracellular delivery of chemical probes using a glutathione-responsive traceless tag
-
A new glutathione (GSH)-responsive traceless tag that facilitates intracellular delivery of small molecule chemical probes has been developed.
- Aoyama, Eriko,Fuchida, Hirokazu,Oshikawa, Yuji,Uchinomiya, Shohei,Ojida, Akio
-
supporting information
p. 7715 - 7718
(2016/07/06)
-
- Penem derivatives
-
There are provided compounds of formula I: STR1 wherein R1 is hydrogen or a C1 -C4 alkyl group either unsubstituted or substituted by one or more substituents chosen from a free or protected hydroxy or halogen atom; R2 is a free or esterified carboxy group or carboxylate anion; R3 and R4 are each independently hydrogen or organic group, X is --O--, STR2 --S--, Q is either (a") free or protected hydroxy, or (b") a C1 -C1 acyloxy, or (c") carbamoyloxy OCONH2, or (d") an optionally substituted heterocyclylthio group, or (e") an optionally substituted imido group, or (f") an optionally substituted quaternary ammonium group or (g") a halogen atom, A and the pharmaceutically or veterinarily acceptable salts thereof. There are provided also methods for preparing compounds of formula I. The compounds of formula I are useful as antibacterial agents.
- -
-
-