- Esterified carboxylic pyrazolone dyes and their in situ CuII/H2O2 catalytic oxidation
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In this paper, we report the studies on in situ CuII/H2O2 catalytic oxidation for esterified carboxylic pyrazolone dyes. Our results reveal that two ortho phenolic hydroxyl pyrazolone based heterocyclic dyes can be prepared successfully by treating corresponding esterified carboxylic pyrazolone dyes with Cu(CH3COO)2·H2O/H2O2 or CuCl2·2H2O/H2O2 in the presence of DMF via the Fenton-type reaction. In addition, when Cu(CH3COO)2·H2O and CuCl2·2H2O were used under the similar reaction condition, respectively, copper(II) complexes with distinguishable nuclearities and coordination modes have been obtained. Furthermore, all the compounds have been spectrally compared, where hydrazone to deprotonated and then to hydrazone configurations have been proved before and after forming the copper(II) intermediates and subsequent demetallization. The acquisition of three intermediate copper(II) complexes of esterified carboxylic pyrazolone dyes herein via the Fenton-type reaction is suggested to provide further understanding on the study of such kind of reaction. As far as we know, this is the first study on esterified carboxylic pyrazolone dyes and also the first attempt on the extension of Fenton-type reactions for CuII/H2O2/pyrazolone system.
- Zhao, Xiao-Lei,Feng, Fan-Da,Zhang, Yi,Hu, Bin,Huang, Wei
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- Three-component reaction for an efficient synthesis of 5-hydroxy-1-phenyl-1H-pyrazoles containing a stable phosphorus ylide moiety
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A concise synthesis of new polysubstituted pyrazoles containing a phosphorane is achieved from readily available organic compounds. This C–H bond functionalization is an efficient means of selectively substituting 4-position of pyrazole to produce a five-membered aromatic ring with a chain containing ylide moiety. This protocol requires no additional catalyst and can be used for other pyrazoles including different substituents.
- Ghonchepour, Ehsan,Islami, Mohammad Reza,Mostafavi, Hamid,Tikdari, Ahmad Momeni
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p. 459 - 463
(2018/03/01)
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- NOVEL RENIN INHIBITOR
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The present invention provides a nitrogen-containing saturated heterocyclic compound of the formula [I] which is useful as a renin inhibitor. wherein R1 is a cycloalkyl group or an alkyl, R22 is an optionally substituted aryl and the like, R is a lower alkyl group, R3, R4, R5 and R6 are the same or different, and are a hydrogen atom, an optionally substituted carbamoyl, an optionally substituted alkyl, or alkoxycarbonyl, or a pharmaceutically acceptable salt thereof.
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Paragraph 0473; 0474
(2015/09/22)
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- Novel β-amino acid derivatives as inhibitors of cathepsin A
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Cathepsin A (CatA) is a serine carboxypeptidase distributed between lysosomes, cell membrane, and extracellular space. Several peptide hormones including bradykinin and angiotensin I have been described as substrates. Therefore, the inhibition of CatA has
- Ruf, Sven,Buning, Christian,Schreuder, Herman,Horstick, Georg,Linz, Wolfgang,Olpp, Thomas,Pernerstorfer, Josef,Hiss, Katrin,Kroll, Katja,Kannt, Aimo,Kohlmann, Markus,Linz, Dominik,Hübschle, Thomas,Rütten, Hartmut,Wirth, Klaus,Schmidt, Thorsten,Sadowski, Thorsten
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p. 7636 - 7649
(2012/11/07)
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- Design, synthesis, computational and biological evaluation of new anxiolytics
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New anxiolytics have been discovered by prediction of biological activity with computer programs pass and derek for a heterogeneous set of 5494 highly chemically diverse heterocyclic compounds (thiazoles, pyrazoles, isatins, a-fused imidazoles and others)
- Geronikaki, Athina,Babaev, Eugeni,Dearden, John,Dehaen, Wim,Filimonov, Dmitrii,Galaeva, Irina,Krajneva, Valentina,Lagunin, Alexey,MacAev, Fliur,Molodavkin, Guenadiy,Poroikov, Vladimir,Pogrebnoi, Serghei,Saloutin, Victor,Stepanchikova, Alla,Stingaci, Eugenia,Tkach, Natalia,Vlad, Liudmila,Voronina, Tatiana
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p. 6559 - 6568
(2007/10/03)
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