78061-29-7

Basic information

• Product Name: Methyl 5-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate
• Synonyms: Methyl 5-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate
• CAS NO: 78061-29-7
• Molecular Formula: C11H10N2O3
• Molecular Weight: 218.2087
• Mol File: 78061-29-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 5-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate(78061-29-7)
• EPA Substance Registry System: Methyl 5-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate(78061-29-7)

Safety Data

• Hazardous Substances Data: 78061-29-7(Hazardous Substances Data)

Usage

General Description

Methyl 5-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate is a chemical compound with the molecular formula C11H10N2O3. It is an ester derivative of the pyrazole-3-carboxylic acid and is commonly used in the pharmaceutical industry for the synthesis of various drugs. methyl 5-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate has important pharmacological properties and has been studied for its potential use in the treatment of various diseases and conditions. Its unique molecular structure makes it a valuable building block in organic synthesis and drug development. Overall, methyl 5-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate plays a significant role in the field of medicinal chemistry and drug discovery.

Upstream product

• 100-63-0 phenylhydrazine 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 67-56-1 methanol 
• 113246-37-0 Methyl 5-methoxy-N-phenylpyrazole-3-carboxylate 
• 59-88-1 phenylhydrazine hydrochloride 

Relevant articles and documents

Esterified carboxylic pyrazolone dyes and their in situ CuII/H2O2 catalytic oxidation

In this paper, we report the studies on in situ CuII/H2O2 catalytic oxidation for esterified carboxylic pyrazolone dyes. Our results reveal that two ortho phenolic hydroxyl pyrazolone based heterocyclic dyes can be prepared successfully by treating corresponding esterified carboxylic pyrazolone dyes with Cu(CH3COO)2·H2O/H2O2 or CuCl2·2H2O/H2O2 in the presence of DMF via the Fenton-type reaction. In addition, when Cu(CH3COO)2·H2O and CuCl2·2H2O were used under the similar reaction condition, respectively, copper(II) complexes with distinguishable nuclearities and coordination modes have been obtained. Furthermore, all the compounds have been spectrally compared, where hydrazone to deprotonated and then to hydrazone configurations have been proved before and after forming the copper(II) intermediates and subsequent demetallization. The acquisition of three intermediate copper(II) complexes of esterified carboxylic pyrazolone dyes herein via the Fenton-type reaction is suggested to provide further understanding on the study of such kind of reaction. As far as we know, this is the first study on esterified carboxylic pyrazolone dyes and also the first attempt on the extension of Fenton-type reactions for CuII/H2O2/pyrazolone system.

NOVEL RENIN INHIBITOR

The present invention provides a nitrogen-containing saturated heterocyclic compound of the formula [I] which is useful as a renin inhibitor. wherein R1 is a cycloalkyl group or an alkyl, R22 is an optionally substituted aryl and the like, R is a lower alkyl group, R3, R4, R5 and R6 are the same or different, and are a hydrogen atom, an optionally substituted carbamoyl, an optionally substituted alkyl, or alkoxycarbonyl, or a pharmaceutically acceptable salt thereof.

Design, synthesis, computational and biological evaluation of new anxiolytics

New anxiolytics have been discovered by prediction of biological activity with computer programs pass and derek for a heterogeneous set of 5494 highly chemically diverse heterocyclic compounds (thiazoles, pyrazoles, isatins, a-fused imidazoles and others)