- SUBSTITUTED 2-PHENYL-PYRIDINE DERIVATIVES
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The present invention relates to compounds of formula I wherein R1, R2, R4, R5, Ra, Rb, n, W and Z are as defined in the application, their preparation and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.
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- SUBSTITUTED 2-PHENYL-PYRIDINE DERIVATIVES
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The present invention relates to compounds of formula (I) wherein R1, R2, R4, R5, Ra, Rb, n, W and Z are as defined in the application, their preparation and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.
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- New derivatives of 6-phenylcomanic acid
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Ethyl 6-phenylcomanic acid with hydrazine hydrate and hydroxylamine gives 4-oxo-6-phenyl-4H/-pyran-2-carbohydrazide and 4-oxo-6-phenyl-4H-pyran-2- carbohydroxamic acid, whereas 6-phenylcomanic acid with ammonia in aqueous DMSO gives 4-hydroxy-6-phenylpico
- Usachev,Obydennov,Kodess,Roeschenthaler,Sosnovskikh
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p. 1248 - 1252
(2010/10/04)
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- Antiallergic agents. 2. N-(1H-tetrazol-5-yl)-6-phenyl-2-pyridinecarboxamides
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A new series of N-(1H-tetrazol-5-yl)-6-phenyl-2-pyridinecarboxamides was prepared to determine the effects of substituents on the benzene and pyridine rings on antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) assay after oral administr
- Honma,Oda,Hashiyama,Hanamoto,Nakai,Inoue,Ishida,Takeda,Ono,Tsuzurahara
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p. 1499 - 1504
(2007/10/02)
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