- A General Scheme For Incorporating Nonnatural Functionality Into Peptides
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We describe a convergent synthesis of ΔGCN4229-248-terpyridyl 1, which contains a terpyridyl ligand attached covalently through a disulfide bond to the proposed DNA binding domain of the yeast transcriptional activator protein GCN4
- Cuenoud, Bernard,Schepartz, Alanna
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- New Approaches to the Synthesis of 2,2′: 6′,2″-Terpyridine and Some of Its Derivatives
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A new two-step procedure has been developed for the synthesis of 2,2′: 6′,2″-terpyridine and 4′-methylsulfanyl-2,2′: 6′,2″-terpyridine in more than 70% yield on the basis of Potts’ condensation. Efficient methods have been proposed for purification of all condensation products.
- Zamalyutin,Bezdenezhnykh,Nichugovskiy,Flid
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p. 419 - 425
(2018/06/12)
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- One-pot synthesis of an Fe(II) bis-terpyridine complex with allosterically regulated electronic properties
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Herein we report the one-pot synthesis of Fe(II) bis-terpyridine complexes with two peripheral square-planar Pt(II) bis-phosphinoalkylthioether moieties. These novel structures, which exhibit allosterically controllable electronic properties, are made by
- MacHan, Charles W.,Sarjeant, Amy A.,Stern, Charlotte L.,Mirkin, Chad A.,Adelhardt, Mario,Sutter, Joerg,Meyer, Karsten
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p. 16921 - 16924,4
(2020/09/02)
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- 4-Vinyl-, 6-Vinyl-, and 4'-Vinyl-2,2':6',2''-terpyridinyl Ligands: Their Synthesis and the Electrochemistry of Their Transition-Metal Coordination Complexes
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4'-Vinyl-2,2':6',2''-terpyridinyl was conveniently prepared from 2-acetylpyridine via α-oxoketene dithioacetal methodology, the intermediate 4'-(methylthio)-2,2':6',2''-terpyridinyl being converted into the corresponding 4'-methyl derivative with methylma
- Potts, Kevin T.,Usifer, Douglas A.,Guadalupe, Ana,Abruna, Hector D.
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p. 3961 - 3967
(2007/10/02)
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- Synthesis of 2,6-Disubstituted Pyridines, Polypyridinyls, and Annulated Pyridines
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1,5-Enediones containing a variety of substituents in the 1,5-positions are formed in good yields by the reaction of methyl ketone enolates, generated with potassium tert-butoxide, with α-oxoketene dithioacetals, the latter being prepared from alkyl, cycloalkyl, aryl, or heteryl methyl ketones, NaH, CS2, and CH3I.Ring closure of the 1,5-enediones with NH4OAc gave 2,6-disubstituted 4-(methylthio)pyridines in good to excellent yields.This procedure is particularly suited for the synthesis of 2,6-diheterylpyridines and provides a simple synthesis of terpyridinyl and other oligopyridines.The methylthio groups in the α-oxoketene dithioacetals may be oxidized to the mono- and disulfoxides with m-chloroperbenzoic acid, but with excess peracid, in addition to oxidation to the disulfone, epoxidation of the double bond also occurs.The pyridine 4-methylthio substituent may also be oxidized to the sulfoxide and to the sulfone, and the latter may be displaced with cyanide ion to form the corresponding 4-carbonitrile.
- Potts, Kevin T.,Cipullo, Michael J.,Ralli, Philip,Theodoridis, George
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p. 3027 - 3038
(2007/10/02)
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