- Synthesis of 2,2-dimethyl-3-(3-methyl phenyl)propanal and its derivatives
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An alternative approach to the synthesis of 2,2-dimethyl-3-(3-methylphenyl) propanal and its derivatives was described. 2,2-Dimethyl-3-(3-methylphenyl) propanal and its derivatives were obtained in middle yields from various substituted alkylaromtics, via bromination and alkylation. Its feature of fragrance was green, reminiscent of leaves, with flowery-aldehydic aspects. Copyright
- Zhang, Jianshui,Huang, Rui,Yan, Qian,Pan, Xiahua,Liu, Feng,Ou, Wenhua
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p. 1290 - 1292
(2013/05/09)
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- PYRROLOY2,3-c¨PYRIDINE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE
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Provision of a compound having a superior proton pump action, which shows an antiulcer activity and the like after conversion to an in vivo proton pump inhibitor, a production method thereof and use thereof. A pyrrolo[2,3-c]pyridine compound represented by the formula: wherein each symbol is as defined in the specification.
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Page/Page column 45
(2010/11/27)
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- Paracyclophanes. Part 58 [1]. On the use of the stilbene-phenanthrene photocyclization in [2.2]paracyclophane chemistry
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The application of the stilbene→phenanthrene photocyclization to [2.2]paracyclophane chemistry has been investigated. For the model system 4-styryl[2.2]paracyclophane (2) to [2.2]phenanthrenoparacyclophane (3) the reaction allows the introduction of alkyl substituants in the 6-, 7-, 8- and 9-position of the phenanthrene moiety. However, when the substituent in the 9-position (bay area of phenanthrene nucleus) becomes too large, viz. tert-butyl, no ring closure is observed anymore. The side products of the process (ring cleavage products of the cyclophane core such as 9 and 10) have been characterized for the first time. Extension of the condensed deck is possible leading to PAH-phanes as demonstrated by the preparation of the chrysenophanes 45 and 60; the cyclization to novel helicenophanes such as 50 also takes place without difficulties. In the case of 1,2-di(4-[2.2] paracyclophanyl)ethene (63) the triply-layered hydrocarbon 65 is produced on irradiation in small amounts.
- Hopf,Hucker,Ernst
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p. 947 - 969
(2008/09/17)
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- 6-Substituted pyridoindolone derivatives, production and therapeutic use thereof
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Compounds of formula: and pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2, R3, R4, and R5, have the meanings given in the description; pharmaceutical compositions comprising said compounds; and processes for preparing said compounds and methods of use thereof.
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Page/Page column 12
(2010/11/27)
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- Synthesis and antirhinovirus activity of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)-9H-purines
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A series of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)purines was synthesized and tested for antirhinovirus activity. Most of the compounds were synthesized by alkylation of 6-chloro-2-(trifluoromethyl)-9H-purine with the appropriate benzyl halide followed by displacement of the chloro group with dimethylamine. Alternatively, 6-(dimethylamino)-2-(trifluoromethyl)purine was alkylated with the appropriate benzyl halide. Although several different aryl substituents provided compounds with IC50's = 0.03 μM against rhinovirus serotype 1B, no congener was significantly more active than the parent 2. Twenty-three compounds were tested against 18 other serotypes, but none exhibited a uniform profile of activity.
- Kelley,Linn,Selway
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p. 1757 - 1763
(2007/10/02)
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- Solvolysis of 2-substituted-9-(ortho-substituted) phenylmethyl)fluoren-9-yltrimethylammonium ions in various solvents
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The solvolytic reaction of several 9-(ortho-substituted phenylmethyl)fluoren-9-yltrimethylammonium salts has been investigated in several different solvents.Substitution and elimination products were found for the reactions in all solvents studied, with the exceptions that rection in both tert-butyl alcohol and chloroform led exclusively to the alkene product.The observed rate constants for alkene formation and the percent alkene were measured and it was found that the di-ortho compounds reacted at a faster rate but produced less alkene than the reaction of the corresponding mono-ortho salts.Hydrogen-deuterium isotope effects were also determined for the various reactions.The results are discussed in terms of the reaction proceeding by way of the E1 mechanism, where steric acceleration promotes the loss of the bulky ammonium leaving group to give the carbocation intermediate.
- Smith, Peter James,Pradhan, Jyotsna
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p. 1060 - 1071
(2007/10/02)
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