- Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs
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A series of analogs of DM235 and MN19, characterized by rings with different size, have been prepared and evaluated for their nootropic activity in the mouse passive-avoidance test. It was found that the optimal ring size for the analogs of DM235, showing endocyclic both amidic groups, is 6 or 7 atoms. For the compounds structurally related to MN19, carrying an exocyclic amide group, the piperidine ring is the moiety which gives the most interesting compounds.
- Guandalini,Martini,Di Cesare Mannelli,Dei,Manetti,Scapecchi,Teodori,Ghelardini,Romanelli
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supporting information; experimental part
p. 1936 - 1939
(2012/04/04)
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- 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME
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The present invention provides 2-substituted-ethynylthiazole derivatives of formula (I): wherein R1, R2 and X are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods of using same.
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Page/Page column 17
(2011/05/03)
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- Tetracyclic benzimidazole derivatives and combinatorial libraries thereof
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The present invention relates to novel tetracyclic benzimidazole derivative compounds of the following formula: wherein R1to R10have the meanings described in here. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing tetracyclic benzimidazole derivative compounds.
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- 2-aminopyridine derivatives and combinatorial libraries thereof
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The present invention relates to novel 2-aminopyridine derivative compounds of the following formula: wherein R1to R5have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing 2-aminopyridine derivative compounds.
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- Quinolinecarboxylic acid derivatives and antibacterial agent containing the same
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Novel quinolinecarboxylic derivatives of the formula: STR1 wherein Z is STR2 in which R1 is hydrogen atom or a lower alkyl, R2 is hydrogen atom, hydroxyl or a lower alkyl and R3 is hydrogen atom, hydroxyl or an amino, and
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