- Generation of an 4-Isoxazolyl Anion Species: Facile Access to Multifunctionalized Isoxazoles
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A direct functionalization of unsubstituted isoxazole (1) was achieved by generation of 4-isoxazolyl anion species (3). An efficient 4-iodination of isoxazole and halogen–metal exchange reaction using a turbo Grignard reagent (iPrMgCl? LiCl) were essentia
- Morita, Taiki,Fuse, Shinichiro,Nakamura, Hiroyuki
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supporting information
p. 13580 - 13584
(2016/10/21)
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- Pyrrolidine modulators of ccr5 chemokine receptor activity
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Pyrrolidine compounds of Formula (I), (wherein R1, R2, R3, R4, R5, R6a, R6b, R7 and R8 are defined herein) are described. The compounds are modulators of CCR5 chemokine receptor activity. The compounds are useful, for example, in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
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- Pyrrolidine modulators of chemokine receptor activity
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The present invention is directed to pyrrolidine compounds of the formula 1: (wherein R1, R2, R3, R4, R5, R6and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
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- Plant growth regulators comprising 4-hydroxyisoxazole and related compounds
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The compound 4-hydroxyisoxazole and its lower alkyl and acyl derivatives are useful as plant growth regulators, particularly as herbicides.
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- ISOLATION, STRUCTURE AND SYNTHESIS OF 4-HYDROXYISOXAZOLE (TRIUMFEROL), A SEED GERMINATION INHIBITOR FROM AN AFRICAN PLANT
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The isolation, characterization and an efficient synthesis of 4-hydroxyisoxazole 1, a plant growth regulator isolated from an African plant is reported.It is a new compound, which despite the simple structure, had eluded synthesis.
- Kusumi, Takenori,Chang, Conway C.,Wheeler, Margaret,Kubo, Isao,Nakanishi, Koji,Naoki, Hideo
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p. 3451 - 3454
(2007/10/02)
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