Anticancer anilinoacridines. A process synthesis of the disubstituted amsacrine analog CI-921
An improved process for the synthesis of bulk quantities of the clinical amsacrine analog CI-921 is reported. Described also are detailed analytical and spectroscopic data for this agent.
Potential antitumor agents. 40. Orally active 4,5-disubstituted derivatives of amsacrine
The DNA-intercalating agent amsacrine is an effective drug for the treatment of human leukemias and lymphomas but has minimal solid tumor activity. As a first step in identifying analogues with a wider spectrum of activity, a comparison was made of the in
Denny,Atwell,Baguley
p. 363 - 367
(2007/10/02)
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