Undirected ortho-selectivity in C–H borylation of arenes catalyzed by NHC platinum(0) complexes
Borylation of arenes with bis(pinacolato)diboron catalyzed by sterically encumbered NHC platinum complexes proceeds predominantly at ortho-position even in the absence of a directing group (o: m: p ratio up to 10: 3: 1). The similar borylation with pinacolborane would proceed less selectively.
Rzhevskiy, Sergey A.,Topchiy, Maxim A.,Golenko, Yulia D.,Gribanov, Pavel S.,Sterligov, Grigorii K.,Kirilenko, Nikita Yu.,Ageshina, Alexandra A.,Bermeshev, Maxim V.,Nechaev, Mikhail S.,Asachenko, Andrey F.
p. 569 - 571
(2020/10/09)
Polycyclic α-amino-ε-caprolactams and related compounds
Disclosed are polycyclic α-amino-ε-caprolactams and related compounds which are useful as synthetic intermediates in the preparation of inhibitors of β-amyloid peptide release and/or its synthesis.
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Page/Page column 43
(2010/02/14)
NK1 ANTAGONIST
The invention is to a compound exhibiting neurokinin inhibitory properties, a pharmaceutical composition comprising same and a method of treatment for neurokinin-meditated conditions.Formula (I)
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Page/Page column 17
(2010/02/09)
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