Synthesis, 470-MHz 1H NMR Spectra, and Activity of Delactonized Derivatives of the Anticancer Drug Etoposide
The anticancer drug etoposide (VP 16-213, 1) contains a highly strained trans-fused γ-lactone.This functionality is readily metabolized to an inactive ring-opened hydroxy acid (2).To prevent this detoxification of the drug and to investigate whether the l
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