Highly efficient microwave-assisted solvent free sequential one-pot multicomponent synthesis of novel 2-hydroxy indenopyridin-5-ones and mechanismic computational study
A sequential one-pot three-component microwave-assisted reaction for the efficient and regioselective synthesis of unprecedented polysubstituted 2-hydroxypyridines has been reported. In brief, 1H-indene-1,3(2H)-dione was reacted with acetamide in the presence of NaOH to give N-(1-oxo-1H-inden-3-yl)acetamide, which was treated in situ with aromatic aldehydes to build up the 2-hydroxy-4-aryl-5H-indeno[1,2-b]pyridin-5-ones without using any oxidant and isolation of intermediate.
Jamali, Marzieh,Sardarian, Ali Reza,Rezaei, Farideh,Ghanbari, Mohammad Mehdi,Mohajeri, Afshan
p. 161 - 171
(2021/11/01)
Synthesis of Heterocycles. Part V. (1) The Synthesis of Substituted Indenopyridines
2-Arylmethylene-1-indanones (1) and 2-arylmethylene-1,3-indanediones (VII) react with active methylene compounds in the presence of ammonium acetate as a basic catalyst to afford substituted pyridines.The postulated routes to the formation of the reported
Eweiss, N. F.
p. 273 - 277
(2007/10/02)
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