- N-(AMINO-THIOCARBONYL)-BENZIMIDCHLORIDE
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The reaction of nickel(II)chelates of N',N'-disubstituted N-benzoyl-thioureas with thionylchloride in a non polar solvent yields N-(amino-thiocarbonyl)-benzimide chlorides.
- Beyer, Lothar,Widera, Roland
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- Thiosemicarbazones and thiadiazines derived from fluorinated benzoylthioureas: Synthesis, crystal structure and anti-Trypanosoma cruzi activity
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A series of thiosemicarbazones was obtained by condensation of halogenated N-(diethylaminothiocarbonyl)benzimidoyl chlorides (3b–3h) with 4,4-dimethyl-3-thiosemicarbazide. The activity of the halogenated compounds against the parasite Trypanosoma cruzi was evaluated and compared to the previously reported activity of the corresponding non-substituted thiosemicarbazone. It was found that the halogen-substitution enhances in most cases the anti-parasitic activity. The meta-fluorinated compound (4g) was identified as the most potent one (IC50= 9.0 μM, CC50 > 200 μM), having a selectivity index (SI = IC50/CC50), which is 4-times higher than that of the non-substituted compound. Slight modification of the reaction conditions employed for the synthesis of some of the benzoylthioureas 3a–3g led to the unexpected formation of novel halogenated 6-amino-1,3,5-thiadiazine-2-thiones.
- Salsi, Federico,Bulh?es Portapilla, Gisele,Schutjajew, Konstantin,Carneiro, Zumira Aparecida,Hagenbach, Adelheid,de Albuquerque, Sérgio,da Silva Maia, Pedro Ivo,Abram, Ulrich
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- Oxidorhenium(V) complexes with tetradentate thiourea derivatives
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Potentially tetradentate, binegative thiocarbamoylbenzamidines derived from o-phenylenediamines (H2L or H3L) are shown to be suitable ligand systems for oxidorhenium(V) cores. They readily react with (NBu 4)[ReOCl4] or [ReOCl3(PPh3) 2] under formation of monoxido complexes of the composition [ReO{(H)L}(Y)] with various co-ligands (Y = ReO4-, F 3CCO2-, Cl- or methanol) or μ-oxido dimers depending on the reaction conditions applied. Representative products were isolated and studied spectroscopically and by X-ray diffraction. Substitutions in the periphery of the ligands allow the introduction of a carboxylic substituent, which may serve as anchor group for future bioconjugation of appropriate rhenium (or technetium) complexes.
- Gomez, Juan Daniel Castillo,Nguyen, Hung Huy,Hagenbach, Adelheid,Abram, Ulrich
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p. 123 - 130
(2012/09/10)
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- N-BENZIMIDOYLCHLORIDE AUS N-BENZOYLTHIO(SELENO)HARNSTOFFEN UND THIOPHOSGEN
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Reactions of thiophosgene with N-benzoylthio(seleno)ureas 1 and 3 yield the N-benzimidoylchlorides 2 and 4.
- Weber, G.,Hartung, J.,Beyer, L.
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p. 3475 - 3476
(2007/10/02)
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- REAKTIONEN AN NICKEL(II)KOORDINIERTEN N-ACYLTHIOHARNSTOFFEN MIT SAEURECHLORIDEN: EIN EINFACHER ZUGANG FUER NEUE THIOHARNSTOFF-DERIVATE
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The reaction of transition metal coordinated N,N-dialkylsubstituted N'-benzoyl thioureas with electrophilic agents differs from the reaction of the non-coordinated ligands.The nickel(II)chelates 1 form with organic acid chlorides RCOCl the N',N'-diacylate
- Beyer, L.,Hartung, J.,Widera, R.
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p. 405 - 412
(2007/10/02)
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