- Preparation method of naphazoline hydrochloride
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The invention relates to the technical field of organic synthesis, in particular to a preparation method of naphazoline hydrochloride, which comprises the following steps: by using alpha-naphthylacetic acid, ethylenediamine and acetone as raw materials, carrying out condensation, cyclization, salification and the like to prepare 4, 5-dihydro-2-(1-naphthyl methyl)-1H-imidazole hydrochloride. Alpha-naphthylacetic acid, ethylenediamine and acetone are used as raw materials to prepare the target product, and the raw materials are easy to obtain and low in price. Condensation, cyclization and salification are adopted, the operation reaction conditions are mild, a large number of side reactions are avoided, and the high yield is obtained. The preparation process is high in coherence, short in time consumption and more efficient and thorough in reaction. The preparation process is simple, reaction conditions are mild, and environmental pollution is avoided.
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Paragraph 0015; 0018-0019
(2021/01/24)
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- Preparation method of naphazoline hydrochloride
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The invention discloses a preparation method of naphazoline hydrochloride. A specific sulfur-containing catalyst CS2, Na2S or thiourea is used for synthesizing naphazoline, and a naphazoline hydrochloride product with high yield, high purity and good powder property is obtained through simple salification and recrystallization processes.
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Paragraph 0040-0042; 0045-0047; 0050-0052; 0055-0057
(2019/08/03)
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- Colloid and nanosized catalysts in organic synthesis: XIII. Synthesis of 2-R-2-imidazolines catalyzed by copper and iron oxide nanoparticles
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The reaction of carboxylic acids with ethylenediamine catalyzed by copper or iron oxide nanoparticles proceeds at 80°C with azeotropic water distilling off during 2-8 h to form 2-R-2-imidazolines. Acyl and diacyl derivatives of ethylenediamine are formed in the reaction as side products.
- Popov,Mokhov,Kalitina
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p. 281 - 285
(2016/04/20)
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- Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives
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The present invention relates a method for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders which comprises administering to an individual a therapeutically effective amount of a compound of formula I wherein R, R1, R2, A and n are as defined in the specification and to their pharmaceutically active salts. The invention also relates to novel compounds of formula I, pharmaceutical compositions containing them, and methods for their preparation.
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Page/Page column 43; 48
(2010/11/28)
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- Feed additive for improving growth in agricultural animals
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By using α-mimetics, particularly compounds of general formulae I to III and the compounds listed in Table I, as feed additives in fattening animals, it has surprisingly been possible to improve the daily weight gain, the utilisation of fodder and the ratio of muscle to fat in favor of the proportion of muscle and protein.
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