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CAS No.: | 835-31-4 |
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Name: | Naphazoline |
Article Data: | 17 |
Molecular Structure: | |
Formula: | C14H15ClN2 |
Molecular Weight: | 210.279 |
Synonyms: | 2-Imidazoline,2-(1-naphthylmethyl)- (7CI,8CI);Naphazoline (6CI);2-(1-Naphthalenylmethyl)-2-imidazoline;2-(1-Naphthylmethyl)-2-imidazoline;Antan;Antigaimorit;Colirio Alfa;Euboral Oftalmico;Imidin;Naphthazoline;Naphthizine;Rhinazine; |
EINECS: | 212-641-5 |
Density: | 1.156 g/cm3 |
Melting Point: | 254 °C |
Boiling Point: | 440.466 °C at 760 mmHg |
Flash Point: | 220.186 °C |
Hazard Symbols: | T |
Risk Codes: | 25 |
Safety: | 45 |
Transport Information: | UN 2811 6.1/PG 2 |
PSA: | 24.39000 |
LogP: | 2.14840 |
Conditions | Yield |
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for 2h; Time; Reflux; | 85% |
With iron oxide In water; benzene at 80℃; for 4h; | 30% |
naphthalen-1-ylacetonitrile
ethylene diamine mono-p-toluenesulfonic acid salt
naphazoline
Conditions | Yield |
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With hydrogenchloride |
naphazoline
Conditions | Yield |
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With ammonia; nickel; isopropyl alcohol at 70℃; under 73550.8 Torr; Hydrogenation.Erhitzen des Reaktionsprodukts unter vermindertem Druck; |
Conditions | Yield |
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With ammonium chloride; zinc(II) chloride |
1-naphthyl tosylate
naphazoline
Conditions | Yield |
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Multi-step reaction with 2 steps 1: diethyl ether View Scheme |
Conditions | Yield |
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With carbon disulfide at 110℃; for 2h; Reagent/catalyst; Temperature; |
Conditions | Yield |
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With hydrogenchloride In acetonitrile at 20℃; Solvent; Large scale; | 92.33% |
With hydrogenchloride In acetone at 5℃; for 0.5h; pH=1; Temperature; Reflux; |
The Naphazoline, with the CAS registry number 835-31-4, is also known as 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-. It belongs to the product category of API. Its EINECS registry number is 212-641-5. This chemical's molecular formula is C14H15ClN2 and molecular weight is 246.74. What's more, its IUPAC name is called 2-(Naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole. Naphazoline is a sympathomimetic agent with marked alpha adrenergic activity. It is a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane. This chemical acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion.
Physical properties about Naphazoline are: (1)ACD/LogP: 2.988; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.99; (4)ACD/LogD (pH 7.4): 1.04; (5)ACD/BCF (pH 5.5): 1.10; (6)ACD/BCF (pH 7.4): 1.25; (7)ACD/KOC (pH 5.5): 10.07; (8)ACD/KOC (pH 7.4): 11.40; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 24.39 Å2; (13)Index of Refraction: 1.64; (14)Molar Refractivity: 65.526 cm3; (15)Molar Volume: 181.848 cm3; (16)Polarizability: 25.976×10-24 cm3; (17)Surface Tension: 44.63 dyne/cm; (18)Density: 1.156 g/cm3; (19)Flash Point: 220.186 °C; (20)Enthalpy of Vaporization: 67.071 kJ/mol; (21)Boiling Point: 440.466 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25 °C.
Uses of Naphazoline: it is used to produce other chemicals. For example, it can produce 2-(1-naphthylmethyl)imidazole. The reaction occurs with solvent toluene and other condition of heating for 200 hours. The yield is 83 %.
When you are dealing with this chemical, you should be very careful. This chemical may cause damage to health at low levels. It is toxic if swallowed. In case of accident or if you feel unwell you should seek medical advice immediately.
You can still convert the following datas into molecular structure:
(1) SMILES: N\1=C(\NCC/1)Cc2cccc3c2cccc3
(2) InChI: InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)
(3) InChIKey: CNIIGCLFLJGOGP-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mammal (species unspecified) | LDLo | intravenous | 10mg/kg (10mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 192, Pg. 141, 1939. | |
mouse | LD50 | intraperitoneal | 62mg/kg (62mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 729, 1979. | |
mouse | LD50 | intravenous | 170mg/kg (170mg/kg) | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 9, Pg. 280, 1950. | |
mouse | LD50 | oral | 270mg/kg (270mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 729, 1979. | |
mouse | LD50 | subcutaneous | 514mg/kg (514mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Russian Pharmacology and Toxicology Vol. 37, Pg. 198, 1974. |
rabbit | LD50 | intravenous | 800ug/kg (.8mg/kg) | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 9, Pg. 280, 1950. | |
rabbit | LD50 | subcutaneous | 950ug/kg (.95mg/kg) | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 9, Pg. 280, 1950. | |
rat | LD50 | subcutaneous | 385mg/kg (385mg/kg) | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 9, Pg. 280, 1950. |