An efficient approach to 2-bromoalken-3-ols by regioselective bromohydroxylation reaction of simple allenes with NBS
A regioselective bromohydroxylation reaction of simple allenes affording 2-bromoalken-3-ols in moderate-to-good yields has been developed by using NBS as the electrophilic reagent in a mixture of 1,4-dioxane/H2O (1:1) at room temperature. Throu
A convenient synthesis of functionalized N-(ethynyl)benzotriazoles
1-(2,2-Dichlorovinyl)benzotriazole (7) was prepared by the reaction of 1-formylbenzotriazole with PPh3/CCl4. Lithiation- substitution of 7 with electrophiles gave a variety of functionalized N-(ethynyl)benzotriazoles 8a-h in 32-84% yields.
Katritzky, Alan R.,Singh, Sandeep K.,Jiang, Rong
p. 3794 - 3797
(2007/10/03)
The stability of butinoline
The stability of butinoline in alkaline and acidic solution was investigated. In alkaline solution the retrosynthesis to benzophenone and 3-pyrrolidino-1-propin was observed, in acidic solution the Meyer-Schuster rearrangement to the corresponding unsaturated amino ketone took place. Thermolysis gave 1,1-diphenyl-2-butin-1-ol in addition to the products of retrosynthesis.