Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors
Improving the gastrointestinal safety profile of nonsteroidal anti-inflammatory drugs (NSAIDs) is an important goal. Herein, we report two strategies, using the nonacidic propyphenazone structure, with potential to overcome the side effects of NSAIDs. Pro
Radwan, Mohamed F.,Dalby, Kevin N.,Kaoud, Tamer S.
p. 983 - 988
(2014/12/10)
Synthesis, characterization, in vitro hydrolysis and pharmacodynamic profiles of potential novel mutual prodrugs of N-(2,3-xylyl anthranilic acid)
In present research work, we report the synthesis, in vitro hydrolysis study and pharmacological evaluation of new mutual prodrugs of mefenamic acid (MA) and 1,2 dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenylpyrazol-3-one with the aim of improving the th
Ohlan, Sucheta,Nanda, Sanju,Pathak, Dharam Pal
p. 5120 - 5128
(2013/12/04)
Biological and metabolic study of naproxen-propyphenazone mutual prodrug
Naproxen-propyphenazone (NAP-PP) esters were synthesized as prodrugs with the aim of improving the therapeutic index through prevention of gastrointestinal irritation and bleeding. The structures of the synthesized NAP-PP hybrid esters were confirmed by I
Sheha, Mahmoud,Khedr, Alaa,Elsherief, Hosny
p. 121 - 130
(2007/10/03)
On the stability of (phenylethylamino)pyrazolones
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Rucker,Mrongovius,Neugebauer
p. 839 - 846
(2007/10/02)
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