83957-89-5Relevant articles and documents
Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors
Radwan, Mohamed F.,Dalby, Kevin N.,Kaoud, Tamer S.
supporting information, p. 983 - 988 (2014/12/10)
Improving the gastrointestinal safety profile of nonsteroidal anti-inflammatory drugs (NSAIDs) is an important goal. Herein, we report two strategies, using the nonacidic propyphenazone structure, with potential to overcome the side effects of NSAIDs. Pro
Biological and metabolic study of naproxen-propyphenazone mutual prodrug
Sheha, Mahmoud,Khedr, Alaa,Elsherief, Hosny
, p. 121 - 130 (2007/10/03)
Naproxen-propyphenazone (NAP-PP) esters were synthesized as prodrugs with the aim of improving the therapeutic index through prevention of gastrointestinal irritation and bleeding. The structures of the synthesized NAP-PP hybrid esters were confirmed by I