- Inhibitors of HIV-1 attachment. Part 11: The discovery and structure-activity relationships associated with 4,6-diazaindole cores
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A series of HIV-1 attachment inhibitors containing a 4,6-diazaindole core were examined in an effort to identify a compound which improved upon the potency and oral exposure of BMS-488043 (2). BMS-488043 (2) is a 6-azaindole-based HIV-1 attachment inhibit
- Bender, John A.,Yang, Zhong,Eggers, Betsy,Gong, Yi-Fei,Lin, Pin-Fang,Parker, Dawn D.,Rahematpura, Sandhya,Zheng, Ming,Meanwell, Nicholas A.,Kadow, John F.
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p. 218 - 222
(2013/02/23)
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- RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF
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Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or trea
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Page/Page column 85
(2011/04/14)
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- The efficient one-step chlorination of methylsulfanyl group on pyrimidine ring system with sulfuryl chloride
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A facile one-step transformation of methylsulfanyl and arylsulfanyl groups on pyrimidine ring system into the corresponding chloride group was achieved using sulfuryl chloride in acetonitrile/dichloromethane.
- Ham, Young Jin,Lee, Duck-Hyung,Choi, Hwan Geun,Hah, Jung-Mi,Sim, Taebo
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experimental part
p. 4609 - 4611
(2010/09/18)
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- Diazaindole-dicarbonyl-piperazinyl antiviral agents
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The invention comprises substituted diazaindole-dicarbonyl-piperazinyl derivatives of general Formula I wherein: Q is selected from the group consisting of — may represent a bond; T is —C(O)— or —CH(CN)—; and —Y— is selected from the group consisting of compositions thereof and their use for treating HIV infection.
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Page/Page column 44
(2008/06/13)
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