853058-42-1

Basic information

• Product Name: ETHYL 4-CHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE-7-CARBOXYLATE
• Synonyms: 4-CHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE-7-CARBOXYLIC ACID ETHYL ESTER;ETHYL 4-CHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE-7-CARBOXYLATE;Ethyl 4-chloro-5H-pyrrolo...;2-d]pyriMidine-7-carboxylate;ethyl 4-chloro-5H-pyrrolo[3
• CAS NO: 853058-42-1
• Molecular Formula: C₉H₈ClN₃O₂
• Molecular Weight: 225.64
• Mol File: 853058-42-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 397.1±37.0 °C(Predicted)
• Appearance: /
• Density: 1.458±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.00±0.40(Predicted)
• CAS DataBase Reference: ETHYL 4-CHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE-7-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-CHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE-7-CARBOXYLATE(853058-42-1)
• EPA Substance Registry System: ETHYL 4-CHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE-7-CARBOXYLATE(853058-42-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 853058-42-1(Hazardous Substances Data)

Usage

General Description

ETHYL 4-CHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE-7-CARBOXYLATE is a chemical compound with the molecular formula C11H9ClN4O2. It is a derivative of pyrrolopyrimidine and belongs to the class of organic compounds known as pyrrolopyrimidines. This chemical is commonly used in medicinal chemistry and pharmaceutical research for its potential biological activities, such as antitumor and antimicrobial properties. Its ethyl ester group makes it suitable for use in organic synthesis and drug formulation.ETHYL 4-CHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE-7-CARBOXYLATE has the potential to be a valuable tool in drug discovery and development.

Upstream product

• 94-05-3 ethyl (ethoxymethylene)cyanoacetate 
• 853058-40-9 diethyl 3-amino-1H-2,4-pyrroledicarboxylate 
• 3473-63-0 formamidine acetic acid 
• 1246223-37-9 C₁₀H₁₁N₃O₂S 
• 853058-41-0 4-hydroxy-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester 

Downstream Products

• 853058-43-2 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid lithium salt 
• 1234616-53-5 ethyl 4-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate 
• 1269667-53-9 N-(3-(N-benzylpropylsulfonamido)-2,6-difluorophenyl)-4-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide 
• 1269667-54-0 4-amino-N-(3-(N-benzylpropylsulfonamido)-2,6-difluorophenyl)-5-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide 
• 1269666-14-9 4-ethylthieno[3,2-d]pyrimidine-7-carboxylic acid [2,6-difluoro-3-(propane-1-sulfonylamino)phenyl]amide 
• 1269667-19-7 4-amino-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid [2,6-difluoro-3-(propane-1-sulfonylamino)phenyl]amide 
• 1269667-20-0 4-methylamino-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid [2,6-difluoro-3-(propane-1-sulfonylamino)phenyl]amide 
• 1269667-84-6 N-(3-(4-methoxybenzylpropylsulfonamido)-2,6-difluorophenyl)-4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide 
• 853058-44-3 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carbonyl chloride 

Relevant articles and documents

Inhibitors of HIV-1 attachment. Part 11: The discovery and structure-activity relationships associated with 4,6-diazaindole cores

A series of HIV-1 attachment inhibitors containing a 4,6-diazaindole core were examined in an effort to identify a compound which improved upon the potency and oral exposure of BMS-488043 (2). BMS-488043 (2) is a 6-azaindole-based HIV-1 attachment inhibit

The efficient one-step chlorination of methylsulfanyl group on pyrimidine ring system with sulfuryl chloride

A facile one-step transformation of methylsulfanyl and arylsulfanyl groups on pyrimidine ring system into the corresponding chloride group was achieved using sulfuryl chloride in acetonitrile/dichloromethane.