- COMPOUNDS HAVING AGONISTIC EFFECT AGAINST GPR84, PREPARATION METHOD FOR COMPOUNDS AND USE OF COMPOUNDS
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The present invention relates to a class of compounds represented by the formula I, or pharmaceutically acceptable salts thereof, methods for their preparation, and application as small molecule tools that function as GPR84 agonists, and their use in preparing a medicament for the treatment of septicemia.
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- Photoinduced, Copper-Catalyzed Carbon-Carbon Bond Formation with Alkyl Electrophiles: Cyanation of Unactivated Secondary Alkyl Chlorides at Room Temperature
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We have recently reported that, in the presence of light and a copper catalyst, nitrogen nucleophiles such as carbazoles and primary amides undergo C-N coupling with alkyl halides under mild conditions. In the present study, we establish that photoinduced, copper-catalyzed alkylation can also be applied to C-C bond formation, specifically, that the cyanation of unactivated secondary alkyl chlorides can be achieved at room temperature to afford nitriles, an important class of target molecules. Thus, in the presence of an inexpensive copper catalyst (CuI; no ligand coadditive) and a readily available light source (UVC compact fluorescent light bulb), a wide array of alkyl halides undergo cyanation in good yield. Our initial mechanistic studies are consistent with the hypothesis that an excited state of [Cu(CN)2]- may play a role, via single electron transfer, in this process. This investigation provides a rare example of a transition metal-catalyzed cyanation of an alkyl halide, as well as the first illustrations of photoinduced, copper-catalyzed alkylation with either a carbon nucleophile or a secondary alkyl chloride.
- Ratani, Tanvi S.,Bachman, Shoshana,Fu, Gregory C.,Peters, Jonas C.
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supporting information
p. 13902 - 13907
(2016/01/15)
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- Hydrocyanation of α,ω-Diynes Catalyzed by Tetracyanonickelate. Regiospecific Synthesis of a New Series of Acyclic Dinitriles
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Hydrocyanation of α,ω-diynes without the use of HCN has been described.Cyanonickelate, prepared by reducing 2- with NaBH4 or Zn in the presence of excess KCN in water or ethylene glycol, catalyzes hydrocyanation of α,ω-diynes, HCC(CH2)nCCH to give quantitatively CH3CH(CN)(CH2)nCH(CN)CH3, a new series of acyclic dinitriles.Importance of the preliminary formation of a (?-acetylene)nickel(0) complex for the hydrocyanation has been suggested.
- Funabiki, Takuzo,Sato, Yoshihiro,Yoshida, Satohiro
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p. 2863 - 2864
(2007/10/02)
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