- New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors
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In the search of a potent cognitive enhancer, a series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides have been synthesized and evaluated as positive allosteric modulators of the AM.PA receptors. In the present work, we focused our efforts on the i
- Francotte, Pierre,Goffin, Eric,Fraikin, Pierre,Lestage, Pierre,Van Heugen, Jean-Claude,Gillotin, Florian,Danober, Laurence,Thomas, Jean-Yves,Chiap, Patrice,Caignard, Daniel-Henri,Pirotte, Bernard,De Tullio, Pascal
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experimental part
p. 1700 - 1711
(2010/08/05)
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- Fluorinated benzothiadiazine compounds
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Compounds of formula (I): wherein: RF represents monofluoro- or polyfluoro-alkyl or monofluoro- or polyfluoro-cycloalkylalkyl, R1 represents hydrogen or a group selected from alkylaminocarbonyl and optionally substituted alkyl, Rsub
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Page/Page column 7
(2008/06/13)
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