860639-28-7Relevant articles and documents
New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors
Francotte, Pierre,Goffin, Eric,Fraikin, Pierre,Lestage, Pierre,Van Heugen, Jean-Claude,Gillotin, Florian,Danober, Laurence,Thomas, Jean-Yves,Chiap, Patrice,Caignard, Daniel-Henri,Pirotte, Bernard,De Tullio, Pascal
experimental part, p. 1700 - 1711 (2010/08/05)
In the search of a potent cognitive enhancer, a series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides have been synthesized and evaluated as positive allosteric modulators of the AM.PA receptors. In the present work, we focused our efforts on the i