CYCLIZATION REACTIONS OF N-(2-CHLOROETHYLCARBAMOYL) AMINO ACIDS
Intramolecular cyclization of the N-(2-chloroethylcarbamoyl) derivatives of glycine, valine and phenylalanine give imidazolidone, oxazoline and hydantoin derivatives.The imidazolidone and oxazoline derivatives possess alkylating activity toward NBP, but the hydantoins do not.N-(2-Chloroethylcarbamoyl)glycine reacts with the mercapto group of cysteine; thus, this alkylating group may be useful for receptor labelling.
Vargha, H. S.,Medzihradszky-Schweiger, H.,Ruff, F.,Medzihradszky, K.
p. 2255 - 2258
(2007/10/02)
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