- Polymethine dyes-loaded solid lipid nanoparticles (SLN) as promising photosensitizers for biomedical applications
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Polymethine dyes (PMD) have proved to be excellent candidates in the biomedical field for potential applications in both diagnostic and therapeutic. However, PMD application in biomedicine is hindered by their poor solubility and stability in physiological conditions. Therefore, the incorporation of these dyes in nanosystems could be important to prevent the formation of dye aggregates in aqueous environment and to protect their photophysical characteristics. In the present work, two PMD based on the benzoindolenine ring (bromine benzo-cyanine-C4 and bromine benzo-squaraine-C4) were incorporated into Solid Lipid Nanoparticles (SLN) to solubilize and stabilize them in aqueous solutions. Obtained SLN showed a high incorporation efficiency for both PMD (≈90%) and not only preserved their spectroscopic properties in the NIR region even under physiological conditions but also improved them. Viability assays showed good biocompatibility of both empty and loaded nanocarriers while the cellular uptake and intracellular localization showed the effective internalization in MCF-7 cells, with a partial mitochondrial localization for CY-SLN. Moreover, in vitro phototoxicity assay showed that cyanine loaded-SLN (CY-SLN) is more photoactive than the free dye.
- Barbero, Nadia,Barolo, Claudia,Chinigò, Giorgia,Fiorio Pla, Alessandra,Gasco, Paolo,Gilardino, Alessandra,Gonzalez-Paredes, Ana,Visentin, Sonja
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- 4,5-benzoindole compound and light-emitting application thereof
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The invention provides a 4,5-benzoindole compound with a structural formula shown in the description. The 4,5-benzoindole compound has better thermal stability, high light emitting efficiency and highlight-emitting purity and can be applied to the fields of organic light-emitting devices, organic solar cells, perovskite batteries, organic thin-film transistors or organic light sensors. The invention also provides an organic light-emitting device. The device comprises an anode, a cathode and organic layers, the organic layers contain at least one layer of a light emitting layer, a hole injection layer, a hole transmission layer, an exciton barrier layer and an electronic transmission layer, and at least one layer of the organic layers contains the 4,5-benzoindole compound shown in a structural formula I. The organic light-emitting device prepared from the 4,5-benzoindole compound has the advantages of good light emitting efficiency, excellent color purity and long service life.
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Paragraph 0048; 0049; 0050
(2018/09/08)
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