879713-65-2

Basic information

• Product Name: 7-Bromo-1,1,2-trimethyl-1H-benzo[e]indole
• Synonyms: 7-BROMO-1,1,2-TRIMETHYL-1H-BENZO[E]INDOLE;6-Bromo-2,3,3-TRIMETHYL-3H-BENZO(E)INDOLE
• CAS NO: 879713-65-2
• Molecular Formula: C15H14BrN
• Molecular Weight: 288.18
• Mol File: 879713-65-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 382.5 °C at 760 mmHg
• Flash Point: 185.2 °C
• Appearance: /
• Density: 1.38
• Refractive Index: 1.634
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 5.08±0.40(Predicted)
• CAS DataBase Reference: 7-Bromo-1,1,2-trimethyl-1H-benzo[e]indole(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Bromo-1,1,2-trimethyl-1H-benzo[e]indole(879713-65-2)
• EPA Substance Registry System: 7-Bromo-1,1,2-trimethyl-1H-benzo[e]indole(879713-65-2)

Safety Data

• Hazardous Substances Data: 879713-65-2(Hazardous Substances Data)

Usage

General Description

7-Bromo-1,1,2-trimethyl-1H-benzo[e]indole is a specialized, complex chemical compound that falls under the class of organic compounds known as benzindoles. This class of compounds is characterized by a benzene ring fused to an indole. The structure of 7-Bromo-1,1,2-trimethyl-1H-benzo[e]indole is further decorated with additional substituents such as bromine and methyl groups at certain positions. These additions and the general structure of the compound lend to its unique physical and chemical properties, which include its solubility, melting point, and possible reactivity with other substances. The specific applications and potential uses of this chemical are often niche and inherently dependent on its inherent chemical structure and properties.

InChI:InChI=1/C15H14BrN/c1-9-15(2,3)14-12-6-5-11(16)8-10(12)4-7-13(14)17-9/h4-8H,1-3H3

Upstream product

• 563-80-4 3-methyl-butan-2-one 

Relevant articles and documents

Polymethine dyes-loaded solid lipid nanoparticles (SLN) as promising photosensitizers for biomedical applications

Polymethine dyes (PMD) have proved to be excellent candidates in the biomedical field for potential applications in both diagnostic and therapeutic. However, PMD application in biomedicine is hindered by their poor solubility and stability in physiological conditions. Therefore, the incorporation of these dyes in nanosystems could be important to prevent the formation of dye aggregates in aqueous environment and to protect their photophysical characteristics. In the present work, two PMD based on the benzoindolenine ring (bromine benzo-cyanine-C4 and bromine benzo-squaraine-C4) were incorporated into Solid Lipid Nanoparticles (SLN) to solubilize and stabilize them in aqueous solutions. Obtained SLN showed a high incorporation efficiency for both PMD (≈90%) and not only preserved their spectroscopic properties in the NIR region even under physiological conditions but also improved them. Viability assays showed good biocompatibility of both empty and loaded nanocarriers while the cellular uptake and intracellular localization showed the effective internalization in MCF-7 cells, with a partial mitochondrial localization for CY-SLN. Moreover, in vitro phototoxicity assay showed that cyanine loaded-SLN (CY-SLN) is more photoactive than the free dye.