- Pyrimidine-pyrazole metal ruthenium complex with catalysis property and preparation method of complex
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The invention discloses a pyrimidine-pyrazole metal ruthenium complex with a catalysis property and a preparation method of the complex and relates to synthesis and an application of a transition metal complex. A molecular formula of the pyrimidine-pyrazo
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Paragraph 0028-0030
(2019/07/04)
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- Copper-Catalyzed C-N Bond Exchange of N-Heterocyclic Substituents around Pyridine and Pyrimidine Cores
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A copper-catalyzed transfer N-heteroarylation strategy using a C-N bond exchange reaction is described. This reaction accommodates a wide range of pyridine and pyrimidine rings bearing halogen atoms, which have wide utility for subsequent transformations. This method provides a direct and operationally simple approach for modifying complex molecules by the exchange of N-heterocyclic substituents.
- Tao, Sheng,Ji, Enhui,Shi, Lei,Liu, Ning,Xu, Liang,Dai, Bin
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p. 5120 - 5130
(2017/11/28)
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- Metal-free site-selective C-N bond-forming reaction of polyhalogenated pyridines and pyrimidines
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This paper presents a metal-free method for highly site-selective C-N bond-forming reaction of polyhalogenated pyridines and pyrimidines. The preferred coupling site can be tuned from the fluorine group bearing the N-heterocyclic ring to the chlorine group when changing from the pyridine ring to the pyrimidine ring. A wide array of halogenated pyridines preferentially reacted with amines at the fluorine group of the pyridine ring to generate monosubstituted halogenated pyridines with high selectivities. Different halogen atoms at various positions were produced by the pyridine ring that performed well under mild conditions. Halogenated pyrimidines underwent highly selective coupling at the chloride group with a wide range of amines having broad substrate applicability and moderate to good yields. The selectivity of the polyfluoropyridines in the developed reaction system was also tested, and the result indicated that the reaction occurred site-selectively at the ortho-position of the nitrogen ring. This reaction accommodated a wide range of halogenated groups. Thus, a wide range of chloro-, bromo-, iodo-, and fluoropyridines were generated, which have a wide utility for organic synthesis.
- Wang, Lei,Liu, Ning,Dai, Bin
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p. 82097 - 82111
(2015/10/12)
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- NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF
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The object of the present invention is to provide a compound and a pharmaceutical composition having excellent Syk inhibitory activity. According to the present invention, a nicotinamide derivative represented by the following formula (I) or a salt thereof is provided, wherein R1 is a substituent represented by the following formula (II-1), (III-1), or (IV-1) (wherein R3, R4, R5, n, and X1 have the same definitions as those described in the specification), and R2 is a pyridyl, indazolyl, phenyl, pyrazolopyridyl, benzisoxazolyl, pyrimidinyl, or quinolyl group, each of which optionally has at least one substituent.
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Paragraph 0901; 0902; 0903; 0904
(2014/10/29)
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- OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS
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The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria, for example, multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms, for example, Bacterioides spp. and Clostridia spp. species, and acid fast organisms, for example, Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
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Page/Page column 84
(2010/10/20)
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