- Modulating Guest Uptake in Core–Shell MOFs with Visible Light
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A two-component core–shell UiO-68 type metal–organic framework (MOF) with a nonfunctionalized interior for efficient guest uptake and storage and a thin light-responsive outer shell was prepared by initial solvothermal MOF synthesis followed by solvent-as
- Mutruc, Dragos,Goulet-Hanssens, Alexis,Fairman, Sam,Wahl, Sebastian,Zimathies, Annett,Knie, Christopher,Hecht, Stefan
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p. 12862 - 12867
(2019/08/08)
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- Thermal decomposition pathways of nitro-functionalized metal-organic frameworks
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The decomposition behavior of high energy metal-organic frameworks (MOFs) with extensive nitration is disclosed. In contrast to the detonation behavior observed in molecular energetic compounds, deflagration transforms cubic MOFs into anisotropic carbon s
- McDonald, Kyle A.,Ko, Nakeun,Noh, Kyungkyou,Bennion, Jonathan C.,Kim, Jaheon,Matzger, Adam J.
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p. 7808 - 7811
(2017/07/15)
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- HEPATITIS B CORE PROTEIN MODULATORS
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The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
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Paragraph 00095
(2017/04/11)
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- SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS RXR AGONISTS
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The present invention relates to certain substituted bicyclic compounds that are agonists of RXR and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders.
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- A significant enhancement of water vapour uptake at low pressure by amine-functionalization of UiO-67
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The functionalization of UiO-67 with -NH2 groups enhances CO2 and CH4 adsorption at 1 bar and 298 K and positively influences the framework's interaction with water as evidenced by the significant enhancement of water vapo
- Ko, Nakeun,Hong, Jisu,Sung, Siyoung,Cordova, Kyle E.,Park, Hye Jeong,Yang, Jin Kuk,Kim, Jaheon
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p. 2047 - 2051
(2015/02/05)
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- BENZAMIDE DERIVATIVE WITH ANTICANCER ACTIVITY AND PREPARATION METHOD AND USE THEREOF
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Provided are a benzamide derivative as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the preparation method and use thereof for preparing a medicine for treating cancer, wherein the group definitions of formula (I) are as set out
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Paragraph 0083; 0084; 0085
(2013/09/12)
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- PROCESS FOR THE PREPARATION OF 4-IODO-3-NITROBENZAMIDE
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A process for the preparation of 4-iodo-3-nitrobenzamide free from the impurities formed due to nucleophilic substitution of the labile iodo group is disclosed.
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Paragraph 0026
(2013/07/19)
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- Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5- carboxylic acid and structural development to increase potency
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We have reported that retinoid X receptor (RXR) partial agonist 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5- carboxylic acid (CBt-PMN, 4a) shows a significant antidiabetes effect in the KK-Ay type 2 diabetes model
- Ohsawa, Fuminori,Yamada, Shoya,Yakushiji, Nobumasa,Shinozaki, Ryosuke,Nakayama, Mariko,Kawata, Kohei,Hagaya, Manabu,Kobayashi, Toshiki,Kohara, Kazutaka,Furusawa, Yuuki,Fujiwara, Chisa,Ohta, Yui,Makishima, Makoto,Naitou, Hirotaka,Tai, Akihiro,Yoshikawa, Yutaka,Yasui, Hiroyuki,Kakuta, Hiroki
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p. 1865 - 1877
(2013/05/09)
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- RXR partial agonist CBt-PMN exerts therapeutic effects on type 2 diabetes without the side effects of RXR full agonists
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Treating insulin resistance and type 2 diabetes in rodents, currently known retinoid X receptor (RXR) agonists induce significant adverse effects. Here we introduce a novel RXR partial agonist CBt-PMN (11b), which shows a potent glucose-lowering effect and improvements of insulin secretion and glucose tolerance without the serious adverse effects caused by RXR full agonists. We suggest that RXR partial agonists may be a new class of antitype 2 diabetes drug candidates.
- Kakuta, Hiroki,Yakushiji, Nobumasa,Shinozaki, Ryosuke,Ohsawa, Fuminori,Yamada, Shoya,Ohta, Yui,Kawata, Kohei,Nakayama, Mariko,Hagaya, Manabu,Fujiwara, Chisa,Makishima, Makoto,Uno, Shigeyuki,Tai, Akihiro,Maehara, Ami,Nakayama, Masaru,Oohashi, Toshitaka,Yasui, Hiroyuki,Yoshikawa, Yutaka
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p. 427 - 432
(2012/06/30)
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- NOVEL MCH RECEPTOR ANTAGONISTS
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The present invention relates to a melanin concentrating hormone antagonist compound of formula I: or a pharmaceutically acceptable salt thereof, useful for the treamtment useful fog treating Type H diabetes and/or obesity.
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Page/Page column 68
(2010/02/11)
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- 1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO
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Compounds of Formula (IA), IB), IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
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Page/Page column 189
(2010/02/11)
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- The solid phase synthesis of tri-substituted indoles
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The palladium-catalyzed solid phase synthesis of tri-substituted indoles is described. The synthesis incorporates three independently variable groups and is ideally suited for the preparation of combinatorial libraries.
- Collini, Michael D.,Ellingboe, John W.
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p. 7963 - 7966
(2007/10/03)
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