- Synthesis and characterization of potential impurities of carvedilol, an antihypertensive drug
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Carvedilol (Coreg) is a nonselective -adrenergic blocking agent with vasodilating activity. It is used for the treatment of congestive heart failure and hypertension. During the bulk synthesis of carvedilol, we have observed six impurities: Imp-I, Imp-II, Imp-III, Imp-IV, Imp-V, and Imp-VI. The present work describes the synthesis and characterization of these impurities. Copyright
- Rao, Somisetti Narender,Sitaramaiah, Devarasetty,Srimannarayana, Kema,Rao, Challa Nageswar,Rao, Peddi Srinivasa,Babu, K. Sudhakar
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experimental part
p. 85 - 93
(2011/03/19)
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- Process for the preparation of carvedilol
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Disclosed herein is a process for preparation of carvedilol substantially free from its bis-impurity comprises the reaction of 4- (2,3- epoxypropoxy)carbazole and 2-(2-methoxyphenoxy)ethylamine in a polar aprotic solvent media; followed by isolation of carvediol from the reaction mass as an acid addition salt and subsequent conversion into pure carvedilol.
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Page/Page column 2-3; 6
(2008/06/13)
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- PROCESS FOR MANUFACTURE OF RACEMIC CARVEDILOL
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The invention relates to a novel process for the manufacture of Carvedilol of high HPLC purity (>99.5 %) having individual impurity less than 0.1 %. The product is isolated from reaction mass as a salt with suitable organic acids which on further purification is converted into the free base i.e., Carvedilol.
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Page/Page column 6-7
(2010/02/13)
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