918903-20-5

Basic information

• Product Name: Carvedilol Bis-carbazole
• Synonyms: 1,1'-[[2-(2-Methoxyphenoxy)ethyl]imino]bis[3-(9H-carbazol-4-yloxy)-2-propanol;Carvedilol Bis-carbazole;Carvedilol Related Compound B;Carvedilol Related Compound B (15 mg) (3,3'-(2-(2-methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol));Carvedilol IMpurity-B(EP);Carvedilol EP IMpurity B;Carvedilol impurity B (PhEur);Carvedilol Related Compound B (USP)
• CAS NO: 918903-20-5
• Molecular Formula: C₃₉H₃₉N₃O₆
• Molecular Weight: 643.72758
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Aromatics;Heterocycles;Impurities
• Mol File: 918903-20-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 905.6±65.0 °C(Predicted)
• Appearance: /
• Density: 1.328±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Very Slight
• PKA: 13.53±0.20(Predicted)
• BRN: 14441019
• CAS DataBase Reference: Carvedilol Bis-carbazole(CAS DataBase Reference)
• NIST Chemistry Reference: Carvedilol Bis-carbazole(918903-20-5)
• EPA Substance Registry System: Carvedilol Bis-carbazole(918903-20-5)

Safety Data

• Hazard Codes: N
• Statements: 51/53
• Safety Statements: 61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 918903-20-5(Hazardous Substances Data)

Usage

Description

Carvedilol Bis-carbazole, also known as Carvedilol EP Impurity B, Carvedilol Impurity B, or Carvedilol USP B, is an impurity derived from the manufacturing process of Carvedilol (C184625), a pharmaceutical drug used for treating high blood pressure, heart failure, and angina.

Uses

Used in Pharmaceutical Industry:
Carvedilol Bis-carbazole is used as a process impurity in the manufacturing of Carvedilol for the treatment of high blood pressure, heart failure, and angina. Its presence is monitored and controlled to ensure the quality and safety of the final pharmaceutical product.

Upstream product

• 787598-91-8 (+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol salicylate 
• 1836-62-0 2-(2-methoxy-phenoxy)-ethylamine 
• 51997-51-4 4-(2,3-epoxypropoxy)carbazole 
• 69-72-7 salicylic acid 
• 52602-39-8 9H-carbazol-4-ol 

Relevant articles and documents

Synthesis and characterization of potential impurities of carvedilol, an antihypertensive drug

Carvedilol (Coreg) is a nonselective -adrenergic blocking agent with vasodilating activity. It is used for the treatment of congestive heart failure and hypertension. During the bulk synthesis of carvedilol, we have observed six impurities: Imp-I, Imp-II, Imp-III, Imp-IV, Imp-V, and Imp-VI. The present work describes the synthesis and characterization of these impurities. Copyright

PROCESS FOR MANUFACTURE OF RACEMIC CARVEDILOL

The invention relates to a novel process for the manufacture of Carvedilol of high HPLC purity (>99.5 %) having individual impurity less than 0.1 %. The product is isolated from reaction mass as a salt with suitable organic acids which on further purification is converted into the free base i.e., Carvedilol.