787598-91-8

Basic information

• Product Name: (+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol salicylate
• Synonyms: (+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol salicylate
• CAS NO: 787598-91-8
• Molecular Weight: 544.604
• Mol File: 787598-91-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol salicylate(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol salicylate(787598-91-8)
• EPA Substance Registry System: (+/-)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)-ethyl]-amino]-2-propanol salicylate(787598-91-8)

Safety Data

• Hazardous Substances Data: 787598-91-8(Hazardous Substances Data)

Upstream product

• 1836-62-0 2-(2-methoxy-phenoxy)-ethylamine 
• 69-72-7 salicylic acid 
• 51997-51-4 4-(2,3-epoxypropoxy)carbazole 

Downstream Products

• 918903-20-5 C₃₉H₃₉N₃O₆ 
• 72956-09-3 carvedilol 

Relevant articles and documents

A PROCESS FOR THE PREPARATION OF CARVEDILOL

The present invention provides a more simplified, cost effective, commercially feasible process for the preparation of Carvedilol (I) comprising a step of reacting 4-hydroxy oarbazole (II) with epichlorohydrin and directly isolating the intermediate 4-(2,3- epoxypropoxy) carbazole (III) which on purification followed by reaction with 2-(2- methoxyphenoxy) ethylamine (IV) yields crude Carvedilol (I). The crude Carvedilol (I) is converted to pure product either through solvent crystallization (without salt formation) or through salt formation followed by salt cleavage and solvent crystallization resulting in highly pure (i.e. ICH grade) Carvedilol.

PROCESS FOR THE PREPARATION OF CARVEDILOL FORM-II

The present invention provides a cost-effective, industrially feasible process for the manufacture of crystalline Carvedilol Form-II using novel Carvedilol salts comprising a step of reacting 4-(2,3-epoxy propoxy) carbazole (II) with 2-(2-methoxy phenoxy) ethyl amine (III) followed by acidification with mineral acid in presence of an organic solvent to yield acid addition salts, treatment of the said salts with base(s) in presence of organic solvent(s), water and isolation from the organic solvent(s) followed by crystallization from ethyl acetate.