cas 92096-37-2, DIPHENYLMETHYL (7R)-3-(MESYLOXY)-7-(PHENYLACETAMIDO)-3,4-DIDEHYDROCEPHAM-4-CARBOXYLATE | Articles data ｜lookchem

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92096-37-2

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MANUFACTURING METHOD OF INTERMEDIATE FOR PREPARATION OF CEPHALOSPORIN DERIVATIVE AND CEFTAROLINE FOSAMIL METAL SALT MANUFACTURED THEREBY
The present invention relates to a method for preparing an intermediate for the preparation of a cephalosporin compound, and a ceftaroline fosamil metal salt obtained therefrom. According to the method for preparing an intermediate for the preparation of
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Paragraph 0084-0085; 0096-0100

(2020/12/01)

CEPHALOSPORIN INTERMEDIATE AND PROCESS FOR ITS PREPARATION
Provided is a synthesis of cephalosporin derivatives, characterized by the use of the new intermediates for the preparation of cephalosporin derivatives, a crystalline toluene hemi-solvate of benzhydryl (6R,7R)-7β-[(phenylacetyl)amino]-3-[4-pyridyl-2-thia
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Page/Page column 18

(2016/09/22)

studies on anti-helicobacter pylori agents. Part 2: New cephem derivatives
The synthesis and optimization of the anti-Helicobacter pylori activity of a novel series of cephem derivatives are described. Introduction of thio-heterocyclic groups containing N- and S-atoms to the 3-position and phenyl or thienyl acetamido groups to the 7-position of the cephem nucleus dramatically improved the activity. From this series of derivatives, compound 13i was found to have extremely potent in vitro anti-H. pylori activity, superior therapeutic efficacy compared to AMPC and CAM, no cross-resistance between CAM or MNZ and low potential for causing diarrhea due to instability to β-lactamase. Copyright (C) 2000 Elsevier Science Ltd.
Yoshida, Yoshiki,Matsuda, Keiji,Sasaki, Hiroshi,Matsumoto, Yoshimi,Matsumoto, Satoru,Tawara, Shuichi,Takasugi, Hisashi
p. 2317 - 2335
(2007/10/03)

Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative
The synthesis and anti-Helicobacter pylori activity of a novel cephem derivative FR182024 (1) are described. FR182024 having a (5-methyl-1,3,4-thiadiazol-2-yl)-thio moiety at the 3-position and a phenylacetamido at the 7-position was found to have extremely potent in vitro anti-H.pylori activity, superior therapeutic efficacy to AMPC and CAM, and low potential for causing diarrhea.
Yoshida, Yoshiki,Matsuda, Keiji,Sasaki, Hiroshi,Matsumoto, Yoshimi,Matsumoto, Satoru,Takasugi, Hisashi
p. 3123 - 3126
(2007/10/03)

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Chemical Properties

Boiling Point: 835.3±65.0 °C (760 mmHg)
Density: 1.46±0.1 g/cm3(20 °C , 760mmHg)
PSA: 152.76000
LogP: 4.55920

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