92096-37-2

Basic information

• Product Name: DIPHENYLMETHYL (7R)-3-(MESYLOXY)-7-(PHENYLACETAMIDO)-3,4-DIDEHYDROCEPHAM-4-CARBOXYLATE
• Synonyms: DIPHENYLMETHYL (7R)-3-(MESYLOXY)-7-(PHENYLACETAMIDO)-3,4-DIDEHYDROCEPHAM-4-CARBOXYLATE;Ceftibuten Related Impurity 5
• CAS NO: 92096-37-2
• Molecular Formula: C₂₉H₂₆N₂O₇S₂
• Molecular Weight: 578.65594
• Mol File: 92096-37-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: DIPHENYLMETHYL (7R)-3-(MESYLOXY)-7-(PHENYLACETAMIDO)-3,4-DIDEHYDROCEPHAM-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIPHENYLMETHYL (7R)-3-(MESYLOXY)-7-(PHENYLACETAMIDO)-3,4-DIDEHYDROCEPHAM-4-CARBOXYLATE(92096-37-2)
• EPA Substance Registry System: DIPHENYLMETHYL (7R)-3-(MESYLOXY)-7-(PHENYLACETAMIDO)-3,4-DIDEHYDROCEPHAM-4-CARBOXYLATE(92096-37-2)

Safety Data

• Hazardous Substances Data: 92096-37-2(Hazardous Substances Data)

Usage

Uses

(7R)-Benzhydryl 3-((methylsulfonyl)oxy)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate is a useful intermediate for organic ysnthesis. Ceftibuten Impurity.

Upstream product

• 54639-48-4 (6R,7R)-benzhydryl 3-hydroxy-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 179035-29-1 benzhydryl 7β-(2-phenylacetamido)-3-(2-pyridyl)thio-3-cephem-4-carboxylate 
• 400827-68-1 4-(2-{[(6R,7R)-2-[(diphenylmethoxy)carbonyl]-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]sulfanyl}-1,3-thiazol-4-yl)pyridine 
• 140157-60-4 (6R,7R)-7-[2-[(Z)-1-Benzhydryloxycarbonyl-vinyloxyimino]-2-(2-tert-butoxycarbonylamino-thiazol-4-yl)-acetylamino]-8-oxo-3-(1-trityl-1H-[1,2,3]triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 140128-60-5 C₆₀H₆₀N₈O₉S₄ 
• 1027600-25-4 (6R,7R)-7-{2-(2-tert-Butoxycarbonylamino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-8-oxo-3-(1-trityl-1H-[1,2,3]triazol-4-ylsulfanylmethylsulfanyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant articles and documents

MANUFACTURING METHOD OF INTERMEDIATE FOR PREPARATION OF CEPHALOSPORIN DERIVATIVE AND CEFTAROLINE FOSAMIL METAL SALT MANUFACTURED THEREBY

The present invention relates to a method for preparing an intermediate for the preparation of a cephalosporin compound, and a ceftaroline fosamil metal salt obtained therefrom. According to the method for preparing an intermediate for the preparation of

studies on anti-helicobacter pylori agents. Part 2: New cephem derivatives

The synthesis and optimization of the anti-Helicobacter pylori activity of a novel series of cephem derivatives are described. Introduction of thio-heterocyclic groups containing N- and S-atoms to the 3-position and phenyl or thienyl acetamido groups to the 7-position of the cephem nucleus dramatically improved the activity. From this series of derivatives, compound 13i was found to have extremely potent in vitro anti-H. pylori activity, superior therapeutic efficacy compared to AMPC and CAM, no cross-resistance between CAM or MNZ and low potential for causing diarrhea due to instability to β-lactamase. Copyright (C) 2000 Elsevier Science Ltd.