4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine H3 Receptor Agonists with in Vivo Central Nervous System Activity
Despite the high diversity of histamine H3 receptor (H3R) antagonist/inverse agonist structures, partial or full H3R agonists have typically been imidazole derivatives. An in-house screening campaign intriguingly afforded
Wágner, Gábor,Mocking, Tamara A. M.,Arimont, Marta,Provensi, Gustavo,Rani, Barbara,Silva-Marques, Bruna,Latacz, Gniewomir,Da Costa Pereira, Daniel,Karatzidou, Christina,Vischer, Henry F.,Wijtmans, Maikel,Kie?-Kononowicz, Katarzyna,De Esch, Iwan J. P.,Leurs, Rob
2-AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR ACTIVITY
2-Aminopyrimidine derivatives of formula (I), wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as modulators of the H4 receptor.
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(2008/06/13)
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