- Preparation method of 4-fluoropyridine-2-amine
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The invention discloses a preparation method of 4-fluoropyridine-2-amine, which comprises the following steps: by using 4-chloropyridine-2-carbonitrile as a raw material, carrying out a halogen exchange reaction, a cyano hydrolysis reaction and a Hofmann degradation reaction to prepare the 4-fluoropyridine-2-amine. The method is simple in synthesis process, mild in reaction condition, high in yield and good in product purity; and the used raw materials are easy to obtain, low in cost and suitable for industrial production.
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