944401-77-8

Basic information

• Product Name: 2-AMINO-4-FLUOROPYRIDINE
• Synonyms: 2-Amino-4-fluoropyridine;4-Fluoropyridin-2-amine;2-PyridinaMine,4-fluoro-;4-Fluoro-pyridin-2-ylamine;4-FLUORO-2-PYRIDINAMINE;2-Amino-4-Fluoropyridine(WX609167)
• CAS NO: 944401-77-8
• Molecular Formula: C₅H₅FN₂
• Molecular Weight: 112.1
• EINECS: 1308068-626-2
• Product Categories: Pyridine;Amines;Pyridines;Fluorine series
• Mol File: 944401-77-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 102 °C
• Boiling Point: 211.49 °C at 760 mmHg
• Flash Point: 81.706 °C
• Appearance: Pale yellow/Solid
• Density: 1.257 g/cm³
• Vapor Pressure: 0.182mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: Refrigerated.
• PKA: 6.42±0.11(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-AMINO-4-FLUOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-FLUOROPYRIDINE(944401-77-8)
• EPA Substance Registry System: 2-AMINO-4-FLUOROPYRIDINE(944401-77-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 944401-77-8(Hazardous Substances Data)

Usage

Description

2-Amino-4-fluoropyridine is a white powder chemical compound that serves as a crucial intermediate in the synthesis of various organic compounds and pharmaceuticals. Its unique structure and properties make it a valuable building block for the development of new drugs and other chemical products.

Uses

Used in Pharmaceutical Industry:
2-Amino-4-fluoropyridine is used as a key intermediate in the synthesis of various pharmaceuticals for [application reason]. Its presence in the molecular structure of these drugs contributes to their therapeutic effects and helps address specific medical needs.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Amino-4-fluoropyridine is utilized as a versatile building block for the creation of a wide range of organic compounds. Its unique chemical properties allow it to be incorporated into complex molecular structures, facilitating the development of new materials and chemical products.

InChI:InChI=1/C5H5FN2/c6-4-1-2-8-5(7)3-4/h1-3H,(H2,7,8)

Upstream product

• 19235-89-3 4-chloro-pyridine-2-carbonitrile 

Downstream Products

• 944401-69-8 5-bromo-4-fluoro-pyridin-2-ylamine 
• 1288979-12-3 C₂₆H₃₁FN₄O₄S 
• 1288977-56-9 (1S,2R,3R)-2.3-dimethyl-1-(8-fluoro-1,2,3,4-tetrahydropyrido[3',4':4,5]imidazo[1,2-a]pyridine-2-sulfonylamino)-2-phenylcyclopropane-1-carboxylic acid 
• 1288978-37-9 phosphoric acid 2-(2-azidomethyl-7-fluoroimidazo[1,2-a]pyridin-3-yl)ethyl ester diphenyl ester 
• 1313408-99-9 ethyl 7-fluoroimidazo[1,2-a] pyridine-3-carboxylate 
• 1159827-76-5 7-fluoroimidazo[1,2-a]pyridine-3-carboxylic acid 
• 1350320-98-7 C₁₄H₉FN₂O₂ 
• 1708971-55-4 N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide 
• 1708975-10-3 6-amino-4-((2-methoxyethyl)amino)nicotinonitrile 
• 1708974-11-1 6-amino-4-fluoronicotinonitrile 
• 1610964-23-2 2-(6-fluoro-2-methylimidazo[1,2-a]pyridin-3-yl)-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine 
• 1610966-53-4 di-tert-butyl 2-(6-fluoro-2-methylimidazo[1,2-a]pyridin-3-yl)-6-(4-(trifluoromethyl)phenylamino)pyrimidin-4-yliminodicarbonate 
• 1260798-14-8 ethyl 7-fluoroimidazo[1,2-a]pyridine-2-carboxylate 

Relevant articles and documents

Preparation method of 4-fluoropyridine-2-amine

The invention discloses a preparation method of 4-fluoropyridine-2-amine, which comprises the following steps: by using 4-chloropyridine-2-carbonitrile as a raw material, carrying out a halogen exchange reaction, a cyano hydrolysis reaction and a Hofmann degradation reaction to prepare the 4-fluoropyridine-2-amine. The method is simple in synthesis process, mild in reaction condition, high in yield and good in product purity; and the used raw materials are easy to obtain, low in cost and suitable for industrial production.