Acridine-based dyes as high-performance near-infrared Raman reporter molecules for cell imaging
A surface-enhanced Raman scattering (SERS) nanoprobe has been proven to be a promising tool for near-infrared (NIR) biomedical imaging and diagnosis because of its high sensitivity and selectivity. However, the development of NIR SERS reporters has been a bottleneck impeding the preparation of ultrasensitive SERS probes. Herein, we report the design and synthesis of a series of SERS reporters in the NIR region based on 10-methylacridine (AD). The AD nanotags (gold nanostar-AD molecules-BSA, AuNS-AD-BSA) exhibit appreciable SERS signals and can be detected at as low as the sub-picomole level. The results of in vitro imaging experiments show that it can be used in live-cell delineation.
Cao, Hui,Du, Jiasheng,He, Wanli,Li, Jinming,Li, Yuzhan,Wang, Dong,Zhou, Yang
p. 3380 - 3385
(2022/02/09)
NSP-SA-NHS dye and preparation method and application thereof
The invention discloses an NSP-SA-NHS dye and a preparation method and application thereof and particularly relates to an NSP-SA-NHS dye having a stronger surface enhanced Raman scattering (SERS) effect and a synthesis and preparation method and applicati
Synthesis and spectroscopic and DNA-binding properties of fluorogenic acridine-containing cyanine dyes
(Chemical Equation Presented) The synthesis of a new subclass of mono- and polymethine cyanine dyes that incorporate an acridinium moiety and that absorb in the orange to near-infrared region of the spectrum is reported. The mono-, tri-, and pentamethine dyes in particular exhibit promising fluorogenic properties. Their ability to aggregate in solution and to interact with B-DNA is also discussed.
Mahmood, Tariq,Paul, Alexis,Ladame, Sylvain
scheme or table
p. 204 - 207
(2010/04/24)
An unusually acidic methyl group directly bound to acridinium cation
9,10-Dimethylacridinium chloride (1: X = Cl) exhibited strong acidity of pH 3.90 (3.4 × 10-3 M, 20 °C) in an aqueous solution. H-D exchange reaction of 1 in D2O indicated that protons in the 9-methyl group dissociated to generated H