Platelet activating factor derivative and synthesis method thereof
The invention belongs to the technical field of chemical synthesis and discloses a platelet activating factor derivative with a formula (I) structure, wherein a substituent group R refers to an acryl group. A synthetic route includes nine-step reaction by taking chiral source S-configuration solketal as a starting reactant. The method is adopted for synthesis of a 2-sulfo platelet activating factor and a derivative thereof for the first time and has advantages of high yield, easiness in separation and the like. Low-cost batch synthesis of 2-S-PAF and the derivative thereof is realized, and significances to activity research of 2-S-PAF and the derivative thereof, biological experiments, clinical application and disease treatment are achieved.
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(2017/08/29)
New synthesis of 2-thio-PAF and related compounds as substrates of PAF acetylhydrolase and phospholipase A2
2-Thio PAF and related compounds (1 a-c) as substrates of PAF acetylhydrolase and phospholipase A2 were synthesized stereoselectively from optically active 2-O-benzylglycerol monoacetate.
Murata,Ikoma,Achiwa
p. 1335 - 1336
(2007/10/02)
Stereospecific synthesis of 2-substituted ether phospholipids
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Bhatia,Hajdu
p. 16 - 20
(2007/10/02)
STEREOSPECIFIC SYNTHESIS OF PAF ANALOGUES. PREPARATION OF 1-HEXADECYL 2-THIOACETYL-2-DEOXYGLYCEROPHOSPHOCHOLINE (2-THIOPAF)
A new stereospecific synthesis of ether-phospholipids leading to 2-ThioPAF is reported.
Bhatia, Suresh K.,Hajdu, Joseph
p. 1729 - 1732
(2007/10/02)
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