- Preparation method of lomefloxacin hydrochloride
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The invention discloses a preparation method of lomefloxacin hydrochloride. The preparation method comprises the steps: with a lomefloxacin hydrochloride cyclization material as a starting raw material, the lomefloxacin hydrochloride finished product is obtained through ethylation reaction, hydrolysis reaction, condensation reaction with 2-methylpiperazine and salt formation; an ethylation reagentused in the ethylation reaction is bromoethane, and bromoethane is directly added; the ethylation reaction temperature is further divided into two sections, firstly, reaction is carried out for 2 h at the temperature of 80-90 DEG C, and then reaction is carried out for 2 h at the temperature of 100-105 DEG C; the hydrolysis reaction is carried out in the presence of glacial acetic acid and purified water. In the ethylation, the reaction yield can be greatly improved by adjusting the reaction temperature; the hydrolysis reaction adopts a part of purified water instead of glacial acetic acid, the yield not only can be guaranteed, but also the production cost is greatly reduced and the discharge of three wastes is reduced.
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Paragraph 0025-0029
(2019/12/25)
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