98079-52-8 Usage
Description
Lomefloxacin hydrochloride is the hydrochloride form of Lomefloxacin, a bactericidal fluoroquinolone agent that is active against both gram-negative and gram-positive organisms. It inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are essential for the transcription and replication of bacterial DNA. This inhibition results in strand breakage of the bacterial chromosome, supercoiling, and resealing, thereby inhibiting DNA replication and transcription.
Uses
Used in Pharmaceutical Industry:
Lomefloxacin hydrochloride is used as an orally bioavailable, broad-spectrum antibiotic for the treatment of various bacterial infections. It is effective against a wide range of bacteria, including N. gonorrhoeae, E. coli, K. pneumoniae, P. vulgaris, S. epidermidis, M. morganii, S. aureus, methicillin-resistant S. aureus (MRSA), H. influenzae, and ampicillin-resistant H. influenzae.
Used in Respiratory Infections:
Lomefloxacin hydrochloride is used as a treatment for respiratory infections, such as bronchitis, due to its ability to inhibit bacterial growth and DNA synthesis.
Used in Urinary Tract Infections:
Lomefloxacin hydrochloride is used as a treatment for urinary tract infections, as it effectively inhibits the growth of bacteria responsible for these infections.
Used in Ophthalmology:
Lomefloxacin hydrochloride is used as eye drops for the treatment of bacterial conjunctivitis, providing a topical treatment option for eye infections.
Used in Otolaryngology:
Lomefloxacin hydrochloride is used as ear drops for the treatment of otitis externa and otitis media, offering a targeted treatment for ear infections.
Chemical Properties:
Lomefloxacin hydrochloride is a white powder with no smell and a bitter taste.
Brand Name:
Maxaquin (Pharmacia) is a brand name under which Lomefloxacin hydrochloride is marketed.
Originator
Foxil,Sarabhai Chemicals,India
References
Wadworth, A. N., and K. L. Goa. "Lomefloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. " Drugs 42.6(1991): 1018-60.
Symonds, W. T., and D. E. Nix. "Lomefloxacin and temafloxacin: two new fluoroquinolone antimicrobials." Clin Pharm 11.9(1992): 753-66.
Check Digit Verification of cas no
The CAS Registry Mumber 98079-52-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,0,7 and 9 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 98079-52:
(7*9)+(6*8)+(5*0)+(4*7)+(3*9)+(2*5)+(1*2)=178
178 % 10 = 8
So 98079-52-8 is a valid CAS Registry Number.
InChI:InChI=1/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H
98079-52-8Relevant articles and documents
Preparation method of lomefloxacin hydrochloride
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Paragraph 0025-0029, (2019/12/25)
The invention discloses a preparation method of lomefloxacin hydrochloride. The preparation method comprises the steps: with a lomefloxacin hydrochloride cyclization material as a starting raw material, the lomefloxacin hydrochloride finished product is obtained through ethylation reaction, hydrolysis reaction, condensation reaction with 2-methylpiperazine and salt formation; an ethylation reagentused in the ethylation reaction is bromoethane, and bromoethane is directly added; the ethylation reaction temperature is further divided into two sections, firstly, reaction is carried out for 2 h at the temperature of 80-90 DEG C, and then reaction is carried out for 2 h at the temperature of 100-105 DEG C; the hydrolysis reaction is carried out in the presence of glacial acetic acid and purified water. In the ethylation, the reaction yield can be greatly improved by adjusting the reaction temperature; the hydrolysis reaction adopts a part of purified water instead of glacial acetic acid, the yield not only can be guaranteed, but also the production cost is greatly reduced and the discharge of three wastes is reduced.
