cas 98619-07-9, 2'-Fluoro-4'-hydroxyacetophenone | Articles data ｜lookchem

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98619-07-9

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A new pathway via intermediate 4-amino-3-fluorophenol for the synthesis of regorafenib
A practical synthetic route to regorafenib, in which the target compound was obtained via a 10-step synthesis starting from 2-picolinic acid, 4-chloro-3-(trifluoromethyl)aniline, and 3-fluorophenol, is reported. Crucial to the strategy is the preparation of 4-amino-3-fluorophenol via Fries and Beckman rearrangements using an economical and practical protocol. The main advantages of the route include inexpensive starting materials and an acceptable overall yield. A scale-up experiment was carried out to provide regorafenib with 99.96% purity in 46.5% total yield.
Du, Fangyu,Zhou, Qifan,Shi, Yajie,Yu, Miao,Sun, Wenjiao,Chen, Guoliang
supporting information
p. 576 - 586
(2019/02/01)

A practical synthesis of 2'-fluoro-4'-hydroxyacetophenone
-
Zhang, Xiao-Bo,Lu, Qun,Xu, Wei-Ming
experimental part
p. 419 - 421
(2009/12/24)

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Chemical Properties

Appearance/Colour :slightly beige to beige-brown powder
Melting Point: 120-124 °C
Boiling Point: 292.7 °C at 760 mmHg
Flash Point:130.8 °C
Density: 1.247 g/cm³
Storage Temp.:Inert atmosphere,Room Temperature
Vapor Pressure: 0.00103mmHg at 25°C
Refractive Index: 1.529
PKA: 7.17±0.18(Predicted)
BRN: 696642
PSA: 37.30000
LogP: 1.73390

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