98619-07-9 Usage
Description
2'-Fluoro-4'-hydroxyacetophenone is an organic compound characterized by the presence of a fluorine atom at the 2' position and a hydroxyl group at the 4' position on an acetophenone backbone. This unique molecular structure endows it with specific chemical properties, making it a versatile building block in various industries.
Uses
Used in Organic Synthesis:
2'-Fluoro-4'-hydroxyacetophenone serves as a key intermediate in organic synthesis, particularly for the production of complex organic molecules and pharmaceutical agents. Its fluorinated and hydroxylated structure allows for selective reactions and the formation of diverse chemical entities.
Used in Pharmaceuticals:
In the pharmaceutical industry, 2'-Fluoro-4'-hydroxyacetophenone is utilized as a building block for the development of new drugs. Its unique properties can contribute to the enhancement of drug efficacy, selectivity, and pharmacokinetics, leading to improved therapeutic outcomes.
Used in Agrochemicals:
2'-Fluoro-4'-hydroxyacetophenone is employed in the agrochemical sector for the synthesis of novel pesticides and herbicides. Its incorporation into these compounds can potentially increase their effectiveness and selectivity, reducing environmental impact and improving crop protection.
Used in Dyestuff:
In the dyestuff industry, 2'-Fluoro-4'-hydroxyacetophenone is used as a precursor for the production of various dyes and pigments. Its distinctive molecular structure can lead to the creation of dyes with improved colorfastness, brightness, and stability, catering to the demands of different applications.
Preparation
Preparation by reaction of acetyl chloride on 3-fluorophenol with aluminium chloride in refluxing ethylene dichloride.
Check Digit Verification of cas no
The CAS Registry Mumber 98619-07-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,6,1 and 9 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 98619-07:
(7*9)+(6*8)+(5*6)+(4*1)+(3*9)+(2*0)+(1*7)=179
179 % 10 = 9
So 98619-07-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H7FO2/c1-5(10)7-3-2-6(11)4-8(7)9/h2-4,11H,1H3
98619-07-9Relevant articles and documents
A new pathway via intermediate 4-amino-3-fluorophenol for the synthesis of regorafenib
Du, Fangyu,Zhou, Qifan,Shi, Yajie,Yu, Miao,Sun, Wenjiao,Chen, Guoliang
supporting information, p. 576 - 586 (2019/02/01)
A practical synthetic route to regorafenib, in which the target compound was obtained via a 10-step synthesis starting from 2-picolinic acid, 4-chloro-3-(trifluoromethyl)aniline, and 3-fluorophenol, is reported. Crucial to the strategy is the preparation of 4-amino-3-fluorophenol via Fries and Beckman rearrangements using an economical and practical protocol. The main advantages of the route include inexpensive starting materials and an acceptable overall yield. A scale-up experiment was carried out to provide regorafenib with 99.96% purity in 46.5% total yield.
