372-20-3Relevant articles and documents
Process development and manufacture of potassium 2-fluoro-6-hydroxyphenyltrifluoroborate
Pawar, Lokesh,Jayaramaiah, Ramesh,Krishnan, Baburaj,Arunachalampillai, Athimoolam,Chen, Ying,Parsons, Andrew T.,Robinson, Jo Anna,Tedrow, Jason S.
, p. 4266 - 4270 (2019)
The development of a phase-appropriate manufacturing-scale synthesis of potassium 2-fluoro-6-hydroxyphenyltrifluoroborate was achieved. Investigations into improving the yield and robustness indicated that pH of the reaction medium is a critical process parameter. Additional development resulted in replacing tartaric acid with citric acid, resulting in improved process robustness and enabling scale-up to >10 kg.
Nickel Hydride Catalyzed Cleavage of Allyl Ethers Induced by Isomerization
Kathe, Prasad M.,Berkefeld, Andreas,Fleischer, Ivana
supporting information, p. 1629 - 1632 (2021/02/09)
This report discloses the deallylation of O - and N -allyl functional groups by using a combination of a Ni-H precatalyst and excess Bronsted acid. Key steps are the isomerization of the O - or N -allyl group through Ni-catalyzed double-bond migration followed by Bronsted acid induced O/N-C bond hydrolysis. A variety of functional groups are tolerated in this protocol, highlighting its synthetic value.
Synthesis method of fluorine-containing phenol structure compound
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Paragraph 0021-0022, (2021/03/13)
The invention discloses a synthesis method of a fluorine-containing phenol structure compound, and belongs to the technical field of chemical synthesis. Fluorine-containing benzoic acid is subjected to a one-pot reaction in a solvent under the action of alkali to obtain fluorine-containing phenate, and fluorine-containing phenol is obtained after acid regulation and dissociation. The synthesis method has the advantages of rich, cheap and easily available raw material structure, short synthesis steps, mild reaction conditions, simple and convenient operation, high synthesis yield, good productquality, wide application range and the like, and is suitable for simple and efficient synthesis of various high-value and high-purity fluorine-containing phenol compounds.