- Novel dihydropyridine derivatives
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Dihydropyridine derivatives and salts thereof represented by the general formula, STR1 which possess excellent calcium antagonist effect, hypotensive effect, platelets aggregation inhibitory effect, phosphodiesterase inhibitory effect, calmodulin inhibitory effect and peroxidized lipid lowering effect, and thus dihydropyridine derivatives and salts thereof are useful as a coronary blood flow improving agent such as coronary vasodilator, hypotensive agent, prophylaxis and treating agents for thrombosis, phophodiesterase inhibitory agent, peroxidized lipid metabolism lowering agent, anti-inflammatory agent and others.
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- Process for preparing novel dihydropyridine derivatives
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Process for preparing dihydropyridine derivatives and salts and esters thereof represented by the general formula STR1 from a phenyl derivative and an enamine derivative in which the phenyl derivative is prepared by reacting a compound of the formula STR2
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- Antihypertensive 1,4-dihydropyridines having a conjugated ester
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1,4-dihydropyridine derivatives represented by the following general formula, STR1 in which R3 is a combination of an unsaturated straight chain hydrocarbon group or derivative thereof connected by a single bond with an unsaturated hydrocarbon group or derivative thereof so that the unsaturated carbon atoms of the two groups are in conjugated relationship. These compounds have a hypotensive action the effective time of which is long, which makes the blood pressure descend slowly, and the toxicity of which is low.
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