99522-79-9

Basic information

• Product Name: Pranidipine
• Synonyms: Pranidipine;1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl 5-[(2E)-3-phenyl-2-propen-1-yl] Ester;FRC 8411;OPC 13340;1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(E)-3-phenyl-2-propenyl] ester;2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-[(E)-3-phenyl-2-propenyl] ester;1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl (2E)-3-phenyl-2-propenyl ester
• CAS NO: 99522-79-9
• Molecular Formula: C₂₅H₂₄N₂O₆
• Molecular Weight: 448.473
• EINECS: 1592732-453-0
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 99522-79-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 140-142°C
• Boiling Point: 618.9 °C at 760 mmHg
• Flash Point: 328.1 °C
• Appearance: yellow solid
• Density: 1.254 g/cm³
• Vapor Pressure: 3.02E-15mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• CAS DataBase Reference: Pranidipine(CAS DataBase Reference)
• NIST Chemistry Reference: Pranidipine(99522-79-9)
• EPA Substance Registry System: Pranidipine(99522-79-9)

Safety Data

• Hazardous Substances Data: 99522-79-9(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

A novel calcium channel antagonist; cardiovascular agent.

InChI:InChI=1/C25H24N2O6/c1-16-21(24(28)32-3)23(19-12-7-13-20(15-19)27(30)31)22(17(2)26-16)25(29)33-14-8-11-18-9-5-4-6-10-18/h4-13,15,23,26H,14H2,1-3H3/b11-8+

Upstream product

• 21731-17-9 methyl 3-aminocrotonate 

Relevant articles and documents

Novel dihydropyridine derivatives

Dihydropyridine derivatives and salts thereof represented by the general formula, STR1 which possess excellent calcium antagonist effect, hypotensive effect, platelets aggregation inhibitory effect, phosphodiesterase inhibitory effect, calmodulin inhibitory effect and peroxidized lipid lowering effect, and thus dihydropyridine derivatives and salts thereof are useful as a coronary blood flow improving agent such as coronary vasodilator, hypotensive agent, prophylaxis and treating agents for thrombosis, phophodiesterase inhibitory agent, peroxidized lipid metabolism lowering agent, anti-inflammatory agent and others.

Antihypertensive 1,4-dihydropyridines having a conjugated ester

1,4-dihydropyridine derivatives represented by the following general formula, STR1 in which R3 is a combination of an unsaturated straight chain hydrocarbon group or derivative thereof connected by a single bond with an unsaturated hydrocarbon group or derivative thereof so that the unsaturated carbon atoms of the two groups are in conjugated relationship. These compounds have a hypotensive action the effective time of which is long, which makes the blood pressure descend slowly, and the toxicity of which is low.