67341-01-9

Basic information

• Product Name: N-BOC-D/L-PHENYLGLYCINOL
• Synonyms: N-BOC-D/L-PHENYLGLYCINOL;N-(tert-Butoxycarbonyl)-DL-2-phenylglycinol;2-(tert-Butoxycarbonylamino)-2-phenylethanol;N-Boc-DL-2-phenylglycinol 2-(tert-Butoxycarbonylamino)-2-phenylethanol;N-Boc-DL-2-phenylglycinol, 98+%;2-(Boc-aMino)-2-phenyl-ethanol;Carbamic acid, N-(2-hydroxy-1-phenylethyl)-, 1,1-dimethylethyl ester;1-Boc-D/L-Phenylglycinol
• CAS NO: 67341-01-9
• Molecular Formula: C₁₃H₁₉NO₃
• Molecular Weight: 237.29
• Mol File: 67341-01-9.mol
• Article Data: 85

Chemical Properties

• Melting Point: 141.0 to 147.0 °C
• Boiling Point: 389.433 °C at 760 mmHg
• Flash Point: 189.322 °C
• Appearance: /
• Density: 1.101±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 1.57E-06mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: 2-8°C
• PKA: 11.55±0.46(Predicted)
• CAS DataBase Reference: N-BOC-D/L-PHENYLGLYCINOL(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-D/L-PHENYLGLYCINOL(67341-01-9)
• EPA Substance Registry System: N-BOC-D/L-PHENYLGLYCINOL(67341-01-9)

Safety Data

• Hazardous Substances Data: 67341-01-9(Hazardous Substances Data)

Usage

Uses

N-Boc-DL-Phenylglycinol is a useful intermediate for organic synthesis.

InChI:InChI=1/C13H19NO3/c1-13(2,3)17-12(16)14-11(9-15)10-7-5-4-6-8-10/h4-8,11,15H,9H2,1-3H3,(H,14,16)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 56613-80-0 D-2-phenylglycinol 
• 100-42-5 styrene 
• 4248-19-5 tert-butyl carbazate 
• 20780-54-5 (S)-styrene oxide 
• 70-11-1 α-bromoacetophenone 
• 2425-28-7 (S)-2-bromo-1-phenylethanol 
• 126923-26-0 (R)-2-azido-2-phenylethan-1-ol 
• 956101-46-5 tert-butyl [(1S)-1-phenylprop-2-en-1-yl]imidocarbonate 
• 87802-71-9 (E)-methyl cinnamyl carbonate 
• 137284-11-8 (2R)-2-N-(tert-butoxycarbonyl)amino-2-phenylethanal 
• 51779-32-9 iminodicarboxylic acid di-tert-butyl ester 
• 15028-40-7 DL-2-phenylglycine methyl ester hydrochloride 
• 177896-09-2 tert-butyl benzylidenecarbamate 

Downstream Products

• 160061-53-0 2-Oxo-butyric acid (R)-2-tert-butoxycarbonylamino-2-phenyl-ethyl ester 
• 606144-71-2 tert-butyl (1R)-2-{[(1R,2S)-3-cyano-1-methyl-2-(phenylseleno)propyl]oxy}-1-phenylethylcarbamate 
• 606144-70-1 tert-butyl (1R)-2-{[(1S,2R)-3-cyano-1-methyl-2-(phenylseleno)propyl]oxy}-1-phenylethylcarbamate 
• 606144-82-5 methyl (3RS,4SR)-4-({(2R)-2-[(tert-butoxycarbonyl)amino]-2-phenylethyl}oxy)-3-(phenylseleno)pentanoate 
• 606144-84-7 methyl (3S,4R)-4-({(2R)-2-[(tert-butoxycarbonyl)amino]-2-phenylethyl}oxy)-4-phenyl-3-(phenylseleno)butanoate 
• 606144-83-6 methyl (3R,4S)-4-({(2R)-2-[(tert-butoxycarbonyl)amino]-2-phenylethyl}oxy)-4-phenyl-3-(phenylseleno)butanoate 
• 141096-35-7 (R)-2-(diphenylphosphanyl)-1-phenylethan-1-amine 
• 140372-83-4 (+)-(1R)-1-phenyl-2-(phenylthio)ethylamine 
• 155273-91-9 (R)-(-)-N-<2,6-bis(1-methylethyl)phenyl>-N'-<2-<(butoxycarbonyl)amino>-2-phenylethyl>urea 

Relevant articles and documents

Construction and activity evaluation of novel dual-target (SE/CYP51) anti-fungal agents containing amide naphthyl structure

With the increase of fungal infection and drug resistance, it is becoming an urgent task to discover the highly effective antifungal drugs. In the study, we selected the key ergosterol bio-synthetic enzymes (Squalene epoxidase, SE; 14 α-demethylase, CYP51) as dual-target receptors to guide the construction of novel antifungal compounds, which could achieve the purpose of improving drug efficacy and reducing drug-resistance. Three different series of amide naphthyl compounds were generated through the method of skeleton growth, and their corresponding target products were synthesized. Most of compounds displayed the obvious biological activity against different Candida spp. and Aspergillus fumigatus. Among of them, target compounds 14a-2 and 20b-2 not only possessed the excellent broad-spectrum anti-fungal activity (MIC50, 0.125–2 μg/mL), but also maintained the anti-drug-resistant fungal activity (MIC50, 1–4 μg/mL). Preliminary mechanism study revealed the compounds (14a-2, 20b-2) could block the bio-synthetic pathway of ergosterol by inhibiting the dual-target (SE/CYP51) activity, and this finally caused the cleavage and death of fungal cells. In addition, we also discovered that compounds 14a-2 and 20b-2 with low toxic and side effects could exert the excellent therapeutic effect in mice model of fungal infection, which was worthy for further in-depth study.

Organoiodine-Catalyzed Enantioselective Intermolecular Oxyamination of Alkenes

Metal-free, catalytic enantioselective intermolecular oxyamination of alkenes is realized by use of organoiodine(I/III) chemistry. The protocol is applicable toward aryl- and alkyl-substituted alkenes with high enantioselectivity and electronically controlled regioselectivity. The oxyaminated products can be easily deprotected in one step to reveal free amino alcohols in high yields without loss of enantioselectivity. A key to our success is the discovery of a virtually unexplored chemical entity, N-(fluorosulfonyl)carbamate, as a bifunctional N,O-nucleophile.

COMPLEMENT MODULATORS AND RELATED METHODS

The present disclosure presents compounds and compositions that interact with complement components. Some compounds inhibit complement activity. Included are small molecule compounds and compositions that function as C5 inhibitor compounds. Methods for inhibiting complement activity and methods of treating complement-related indications with the C5 inhibitor compounds and compositions are provided.