86060-93-7

Basic information

• Product Name: FMOC-TYR(TBU)-OPFP
• Synonyms: N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-T-BUTYL-L-TYROSINE PENTAFLUORPHENYL ESTER;N-ALPHA-FMOC-O-T-BUTYL-L-TYROSINE PENTAFLUOROPHENYL ESTER;FMOC-L-TYR(TBU)-OPFP;FMOC-TYR(TBU)-OPFP;FMOC-TYROSINE(TBU)-OPFP;FMOC-TYR(BUT)-OPFP;FMOC-O-TERT-BUTYL-L-TYROSINE PENTAFLUOROPHENYL ESTER;FMOC-O-T-BUTYL-L-TYROSINE PENTAFLUOROPHENYL ESTER
• CAS NO: 86060-93-7
• Molecular Formula: C₃₄H₂₈F₅NO₅
• Molecular Weight: 625.58
• Product Categories: Amino Acids;Fmoc-Amino Acids and Derivatives;Fmoc-Amino acid series
• Mol File: 86060-93-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 61-64℃
• Boiling Point: 713.3 °C at 760 mmHg
• Flash Point: 385.2 °C
• Appearance: White/Powder
• Density: 1.334 g/cm³
• Vapor Pressure: 3.38E-20mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: 2-8°C
• BRN: 4223194
• CAS DataBase Reference: FMOC-TYR(TBU)-OPFP(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-TYR(TBU)-OPFP(86060-93-7)
• EPA Substance Registry System: FMOC-TYR(TBU)-OPFP(86060-93-7)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 86060-93-7(Hazardous Substances Data)

Usage

Description

FMOC-TYR(TBU)-OPFP is a chemical compound that consists of a 9-fluorenylmethoxycarbonyl (Fmoc) group, a tyrosine residue with a tert-butyl (TBU) protecting group, and an ortho-(2,4-dichlorophenyl)phenyl (OPFP) moiety. It is a building block used in the synthesis of peptides and other organic compounds.

Uses

Used in Pharmaceutical Industry:
FMOC-TYR(TBU)-OPFP is used as a synthetic intermediate for the preparation of pharmaceutical compounds. Its Fmoc group allows for the selective protection and deprotection of the tyrosine residue during peptide synthesis, while the OPFP moiety can be used for further functionalization or modification of the compound.
Used in Chemical Research:
FMOC-TYR(TBU)-OPFP is used as a research tool in the field of organic chemistry. Its unique structure allows for the study of various chemical reactions and the development of new synthetic methods.
Used in Peptide Synthesis:
FMOC-TYR(TBU)-OPFP is used as a building block in the solid-phase synthesis of peptides. Its Fmoc group provides a convenient method for the stepwise assembly of peptide chains, while the TBU protecting group ensures the selective protection of the tyrosine side chain during the synthesis process.

InChI:InChI=1/C34H28F5NO5/c1-34(2,3)45-19-14-12-18(13-15-19)16-25(32(41)44-31-29(38)27(36)26(35)28(37)30(31)39)40-33(42)43-17-24-22-10-6-4-8-20(22)21-9-5-7-11-23(21)24/h4-15,24-25H,16-17H2,1-3H3,(H,40,42)/t25-/m0/s1

Upstream product

• 14533-84-7 pentafluorophenyl trifloroacetate 
• 71989-38-3 Fmoc-Tyr(tBu)-OH 
• 771-61-9 2,3,4,5,6-pentafluorophenol 

Downstream Products

• 1026512-33-3 3-[(S)-2-{(S)-6-Amino-2-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-hexanoylamino}-3-(4-hydroxy-phenyl)-propionylamino]-propionic acid 
• 1025806-35-2 3-[(S)-2-{(S)-6-Amino-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-hexanoylamino}-3-(4-hydroxy-phenyl)-propionylamino]-propionic acid 
• 1028254-31-0 6-[(S)-2-{(S)-6-Amino-2-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-hexanoylamino}-3-(4-hydroxy-phenyl)-propionylamino]-hexanoic acid 
• 1027903-88-3 4-[(S)-2-{(S)-6-Amino-2-[(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-hexanoylamino}-3-(4-hydroxy-phenyl)-propionylamino]-butyric acid 
• 105751-14-2 N^α-Fmoc-Tyr-OPfp 
• 252570-73-3 C₆₉H₁₀₄N₁₈O₁₅S 
• 252570-79-9 C₈₂H₁₁₅N₂₁O₁₆S 
• 252570-74-4 C₇₁H₁₀₅N₁₉O₁₅S 
• 252570-75-5 C₆₆H₁₀₅N₁₉O₁₆S 
• 252570-77-7 C₇₄H₁₁₀N₂₀O₁₆S 
• 252570-76-6 C₇₄H₁₁₀N₂₀O₁₆S 

Relevant articles and documents

PREPARATION OF PENTAFLUOROPHENYL ESTERS OF FMOC PROTECTED AMINO ACIDS WITH PENTAFLUOROPHENYL TRIFLUOROACETATE

A high yield procedure for the preparation of pentafluorophenyl esters of Nα-9-fluorenylmethyloxycarbonyl protected amino acids is described.The procedure utilizes pentafluorophenyl trifluoroacetate.